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Tbio
PLXDC1
Plexin domain-containing protein 1

Protein Summary
Description
Plays a critical role in endothelial cell capillary morphogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315392
  • ENSP00000323927
  • ENSG00000161381
  • ENST00000578390
  • ENSP00000462089

Symbol
  • TEM3
  • TEM7
  • TEM3
  • TEM7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.75
PubMedID
0.74
microRNA
0.7
cell line
0.62
gene perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.32   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.32   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
CD248
Tbio
Novelty:  0.00063383
Score:  0.848
Data Source:  STRINGDB
RASD2
Tbio
Family:  Enzyme
Novelty:  0.00490468
Score:  0.792
Data Source:  STRINGDB
NRF1
Tbio
Family:  TF
Novelty:  0.00543248
Score:  0.723
Data Source:  STRINGDB
ARHGEF17
Tbio
Novelty:  0.03360149
Score:  0.71
Data Source:  STRINGDB
ADGRA2
Tbio
Family:  GPCR
Novelty:  0.02854335
Score:  0.709
Data Source:  STRINGDB
TNS3
Tbio
Novelty:  0.01631198
Score:  0.705
Data Source:  STRINGDB
NID1
Tbio
Novelty:  0.00169075
Score:  0.611
Data Source:  STRINGDB
ANTXR1
Tbio
Novelty:  0.00508081
Score:  0.589
Data Source:  STRINGDB
TRARG1
Tbio
Novelty:  0.07729433
Score:  0.549
Data Source:  STRINGDB
PADI4
Tchem
Family:  Enzyme
Novelty:  0.0024252
Score:  0.549
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
3
2
13
92.1
creatinine measurement
1
2
2
50.5
mathematical ability
1
1
1
31.4
self reported educational attainment
1
1
1
24.5
red blood cell distribution width
1
1
1
7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
13
92.1
creatinine measurement
2
50.5
mathematical ability
1
31.4
self reported educational attainment
1
24.5
red blood cell distribution width
1
7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
plexin domain containing 1
VGNC:12598
454623
Macaque
plexin domain containing 1
695635
Mouse
MGI:1919574
72324
Rat
RGD:1307496
303505
Dog
plexin domain containing 1
VGNC:44716
491032
Species
Name
OMA
EggNOG
Inparanoid
Chimp
plexin domain containing 1
Macaque
plexin domain containing 1
Mouse
Rat
Dog
plexin domain containing 1
Publication Statistics
PubMed Score 98.32
PubMed score by year
PubTator Score 19.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title