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Tbio
ZDHHC17
Palmitoyltransferase ZDHHC17

Protein Summary
Description
Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15603740, PubMed:15489887, PubMed:19139280, PubMed:28757145). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793). May play a role in Mg(2+) transport (PubMed:18794299).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000426126
  • ENSP00000403397
  • ENSG00000186908

Symbol
  • HIP14
  • HIP3
  • HYPH
  • KIAA0946
  • HIP3
  • HYPH
  • HIP14
  • DHHC-17
  • HSPC294
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
histone modification site profile
0.84
transcription factor binding site profile
0.82
cellular component
0.66
microRNA
0.64


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.66   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.66   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger DHHC-type containing 17
VGNC:8614
452088
Macaque
zinc finger DHHC-type containing 17
693595
Mouse
MGI:2445110
320150
Rat
RGD:1595790
366889
Dog
zinc finger DHHC-type containing 17
VGNC:48583
482574
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger DHHC-type containing 17
Macaque
zinc finger DHHC-type containing 17
Mouse
Rat
Dog
zinc finger DHHC-type containing 17
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IUH5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (91)
1 – 10 of 91
ARSE
Tbio
Family: Enzyme
Novelty: 0.00151862
p_int: 0.999613396
p_ni: 0.000386604
Data Source: BioPlex
LPAR1
Tchem
Family: GPCR
Novelty: 0.00318056
p_int: 0.999439639
p_ni: 0.000560355
p_wrong: 5e-9
Data Source: BioPlex
PLSCR4
Tbio
Family: Enzyme
Novelty: 0.12079798
p_int: 0.998592935
p_ni: 0.001407065
Score: 0.252
Data Source: BioPlex,STRINGDB
DHX57
Tdark
Family: Enzyme
Novelty: 0.8244078
p_int: 0.998509241
p_ni: 0.001490759
Data Source: BioPlex
PLAC8L1
Tdark
Novelty: 2.10744169
p_int: 0.998335283
p_ni: 0.001664716
Score: 0.551
Data Source: BioPlex,STRINGDB
C3AR1
Tchem
Family: GPCR
Novelty: 0.00527301
p_int: 0.998156909
p_ni: 0.001843091
Data Source: BioPlex
IPPK
Tbio
Family: Enzyme
Novelty: 0.02169701
p_int: 0.998145351
p_ni: 0.001854649
Data Source: BioPlex
AOPEP
Tbio
Family: Enzyme
Novelty: 0.03344862
p_int: 0.989136232
p_ni: 0.010858975
p_wrong: 0.000004793
Score: 0.199
Data Source: BioPlex,STRINGDB
TNFRSF19
Tbio
Novelty: 0.01295599
p_int: 0.986981251
p_ni: 0.013018749
Score: 0.518
Data Source: BioPlex,STRINGDB
FAM135B
Tbio
Novelty: 0.19852891
p_int: 0.977444823
p_ni: 0.022555177
Score: 0.527
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  36.66

PubMed score by year
PubTator Score  17.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer