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Tbio
RBM45
RNA-binding protein 45

Protein Summary
Description
RNA-binding protein with binding specificity for poly(C). May play an important role in neural development. This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286070
  • ENSP00000286070
  • ENSG00000155636
  • ENST00000616198
  • ENSP00000482083

Symbol
  • DRB1
  • DRBP1
  • DRB1
  • RB-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.87
kinase perturbation
0.84
transcription factor perturbation
0.84
transcription factor binding site profile
0.8
histone modification site profile
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.12   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.12   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
1
1
62.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
62.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 45
VGNC:2799
459774
Macaque
RNA binding motif protein 45
702714
Mouse
MGI:2387367
241490
Rat
RGD:628862
266631
Dog
RNA binding motif protein 45
VGNC:53104
478815
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 45
Macaque
RNA binding motif protein 45
Mouse
Rat
Dog
RNA binding motif protein 45
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IUH3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (60)
1 – 10 of 60
WBP4
Tbio
Novelty: 0.10095907
p_int: 0.999995893
p_ni: 0.000004107
Score: 0.187
Data Source: BioPlex,STRINGDB
DKK1
Tchem
Novelty: 0.00117121
p_int: 0.999988461
p_ni: 0.000011539
Score: 0.211
Data Source: BioPlex,STRINGDB
ELAVL2
Tbio
Novelty: 0.00370708
p_int: 0.999978518
p_ni: 0.000021482
Data Source: BioPlex
FOXRED2
Tdark
Family: Enzyme
Novelty: 0.33139597
p_int: 0.999935376
p_ni: 0.000064624
Score: 0.188
Data Source: BioPlex,STRINGDB
DEF6
Tbio
Novelty: 0.0378487
p_int: 0.999862082
p_ni: 0.000137712
p_wrong: 2.06e-7
Score: 0.185
Data Source: BioPlex,STRINGDB
RBM42
Tdark
Novelty: 0.37655036
p_int: 0.999800312
p_ni: 0.000199679
p_wrong: 9e-9
Data Source: BioPlex
RBMX
Tbio
Novelty: 0.01705784
p_int: 0.999799023
p_ni: 0.000200903
p_wrong: 7.4e-8
Score: 0.635
Data Source: BioPlex,STRINGDB
DNAJC25
Tdark
Novelty: 1.55044803
p_int: 0.999695574
p_ni: 0.000304426
Data Source: BioPlex
MAP7
Tbio
Novelty: 0.01976296
p_int: 0.995083806
p_ni: 0.004916193
p_wrong: 1e-9
Data Source: BioPlex
ZFC3H1
Tbio
Novelty: 0.17313739
p_int: 0.988328412
p_ni: 0.011665951
p_wrong: 0.000005637
Score: 0.243
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  17.12

PubMed score by year
PubTator Score  3.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer