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Tbio
KRTAP1-3
Keratin-associated protein 1-3

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344363
  • ENSP00000344420
  • ENSG00000221880
  • ENST00000575715
  • ENSP00000461303
  • ENSG00000262347

Symbol
  • B2B
  • KAP1.2
  • KAP1.3
  • KAP1.8
  • KAP1.9
  • KRATP1.9
  • KRTAP1.8
  • KAP1.2
  • KAP1.3
  • KAP1.6
  • KAP1.9
  • KAP1.8A
  • KAP1.8B
  • KRTAP1.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
tissue
0.56
cell line
0.53
cell type or tissue
0.45
kinase perturbation
0.42


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.46   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.46   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IUG1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (18)
1 – 10 of 18
CDKN3
Tbio
Family: Enzyme
Novelty: 0.00093913
Score: 0.643
Data Source: STRINGDB
CD5
Tbio
Novelty: 0.00032883
Score: 0.641
Data Source: STRINGDB
KRTAP11-1
Tbio
Novelty: 0.20865014
Score: 0.58
Data Source: STRINGDB
CR2
Tbio
Novelty: 0.00086638
Score: 0.538
Data Source: STRINGDB
KRTAP3-2
Tdark
Novelty: 1.99836821
Score: 0.533
Data Source: STRINGDB
CD19
Tclin
Novelty: 0.0001816
Score: 0.532
Data Source: STRINGDB
TNFSF13B
Tclin
Novelty: 0.00069885
Score: 0.53
Data Source: STRINGDB
KRTAP8-1
Tbio
Novelty: 0.18211237
Score: 0.529
Data Source: STRINGDB
SPN
Tbio
Novelty: 0.00121061
Score: 0.528
Data Source: STRINGDB
KRTAP3-3
Tdark
Novelty: 1.72994972
Score: 0.494
Data Source: STRINGDB
Publication Statistics
PubMed Score  35.46

PubMed score by year
PubTator Score  2.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer