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Tbio
HIST2H2AB
Histone H2A type 2-B

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331128
  • ENSP00000332790
  • ENSG00000184270

Symbol
  • H2AB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.79
cell type or tissue
0.73
transcription factor binding site profile
0.68
interacting protein
0.62
tissue sample
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.31   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.31   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
histone cluster 2, H2ab
705170
Mouse
MGI:2448314
621893
Rat
RGD:1584064
690102
Horse
histone H2A type 2-B
106783189
Cow
histone cluster 2, H2ab
614974
Species
Name
OMA
EggNOG
Inparanoid
Macaque
histone cluster 2, H2ab
Mouse
Rat
Horse
histone H2A type 2-B
Cow
histone cluster 2, H2ab
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IUE6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deubiquitination
Reactome
HATs acetylate histones
Reactome
HDACs deacetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Deubiquitination
HATs acetylate histones
HDACs deacetylate histones
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (207)
1 – 10 of 207
H2AFX
Tbio
Novelty: 0.00048694
p_int: 0.999973753
p_ni: 0.000026247
Data Source: BioPlex
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.995214042
p_ni: 0.004785953
p_wrong: 4e-9
Score: 0.97
Data Source: BioPlex,STRINGDB
FAM24B
Tdark
Novelty: 1.04675689
p_int: 0.991974892
p_ni: 0.008013579
p_wrong: 0.000011529
Data Source: BioPlex
XPC
Tbio
Novelty: 0.00775175
p_int: 0.989673869
p_ni: 0.010303629
p_wrong: 0.000022501
Score: 0.653
Data Source: BioPlex,STRINGDB
H1FNT
Tdark
Novelty: 0.05593238
p_int: 0.983593466
p_ni: 0.014979273
p_wrong: 0.001427261
Data Source: BioPlex
H2AFY2
Tbio
Novelty: 0.09948698
p_int: 0.977237917
p_ni: 0.02276208
p_wrong: 3e-9
Score: 0.603
Data Source: BioPlex,STRINGDB
ZNF491
Tdark
Family: TF
Novelty: 4.75862069
p_int: 0.972788213
p_ni: 0.027195226
p_wrong: 0.000016562
Score: 0.17
Data Source: BioPlex,STRINGDB
HIST1H3A
Tbio
Novelty: 0.00991842
p_int: 0.937291331
p_ni: 0.062678664
p_wrong: 0.000030006
Score: 0.809
Data Source: BioPlex,STRINGDB
SSRP1
Tbio
Family: TF
Novelty: 0.0143993
p_int: 0.935107288
p_ni: 0.064892531
p_wrong: 1.8e-7
Score: 0.645
Data Source: BioPlex,STRINGDB
RPS13
Tbio
Novelty: 0.0019983
p_int: 0.924046605
p_ni: 0.073160226
p_wrong: 0.002793169
Score: 0.194
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  11.31

PubMed score by year
PubTator Score  4.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer