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Tbio
RNF135
E3 ubiquitin-protein ligase RNF135

Protein Summary
Description
Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production. The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324689
  • ENSP00000323693
  • ENSG00000181481
  • ENST00000328381
  • ENSP00000328340
  • ENST00000535306
  • ENSP00000440470

Symbol
  • L13
  • MMFD
  • REUL
  • Riplet
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
histone modification site profile
0.88
kinase perturbation
0.84
PubMedID
0.7
virus perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.99   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.99   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
3
4
86.4
BMI-adjusted waist circumference
3
3
4
85
body height
2
1
1
6
82.7
mean corpuscular volume
1
1
1
79.4
mean reticulocyte volume
1
1
1
74.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
4
86.4
BMI-adjusted waist circumference
4
85
body height
1
6
82.7
mean corpuscular volume
1
79.4
mean reticulocyte volume
1
74.6
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 135
VGNC:9565
454562
Mouse
MGI:1919206
71956
Rat
RGD:1307023
303351
Cow
ring finger protein 135
511125
Pig
ring finger protein 135
100522211
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 135
Mouse
Rat
Cow
ring finger protein 135
Pig
ring finger protein 135
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IUD6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Deubiquitination
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Deubiquitination
Immune System
Innate Immune System
Metabolism of proteins
Protein-Protein Interactions (73)
1 – 10 of 73
BSPRY
Tdark
Novelty:  0.38200913
p_int:  0.999993299
p_ni:  0.0000067
p_wrong:  1e-9
Data Source:  BioPlex
CTNNAL1
Tbio
Novelty:  0.03667606
p_int:  0.999733949
p_ni:  0.000265989
p_wrong:  6.2e-8
Score:  0.247
Data Source:  BioPlex,STRINGDB
IQCB1
Tbio
Novelty:  0.02979098
p_int:  0.999715562
p_ni:  0.000281621
p_wrong:  0.000002817
Score:  0.199
Data Source:  BioPlex,STRINGDB
GTF2H2
Tbio
Novelty:  0.02761619
p_int:  0.99945877
p_ni:  0.000541228
p_wrong:  2e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
XRCC4
Tbio
Novelty:  0.00305644
p_int:  0.997978216
p_ni:  0.002021784
Score:  0.167
Data Source:  BioPlex,STRINGDB
TXLNA
Tbio
Novelty:  0.02549959
p_int:  0.98411983
p_ni:  0.01588017
Score:  0.159
Data Source:  BioPlex,STRINGDB
TES
Tbio
Novelty:  0.00052221
p_int:  0.956241064
p_ni:  0.043756013
p_wrong:  0.000002923
Score:  0.173
Data Source:  BioPlex,STRINGDB
EPB41L5
Tbio
Novelty:  0.0391959
p_int:  0.911623238
p_ni:  0.088376762
Data Source:  BioPlex
KLHL42
Tdark
Novelty:  0.25822395
p_int:  0.836904847
p_ni:  0.163095153
Score:  0.185
Data Source:  BioPlex,STRINGDB
DDX58
Tbio
Family:  Enzyme
Novelty:  0.00080099
Score:  0.992
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  16.99

PubMed score by year
PubTator Score  16.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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