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Tbio
TICAM1
TIR domain-containing adapter molecule 1

Protein Summary
Description
Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines (By similarity). This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-trans ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248244
  • ENSP00000248244
  • ENSG00000127666

Symbol
  • PRVTIRB
  • TRIF
  • TRIF
  • IIAE6
  • MyD88-3
  • PRVTIRB
  • TICAM-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
biological process
0.95
histone modification site profile
0.76
cell type or tissue
0.73
biological term
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.2   (req: < 5)
Gene RIFs: 81   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.2   (req: >= 5)
Gene RIFs: 81   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (104)
1 – 10 of 104
CARM1
Tchem
Family:  Epigenetic
Novelty:  0.00623937
p_int:  0.870145073
p_ni:  0.129854927
Score:  0.527
Data Source:  BioPlex,STRINGDB
TLR3
Tbio
Novelty:  0.00057048
Score:  0.998
Data Source:  Reactome,STRINGDB
TRAF3
Tbio
Novelty:  0.0022525
Score:  0.996
Data Source:  Reactome,STRINGDB
TLR4
Tchem
Novelty:  0.00010863
Score:  0.996
Data Source:  Reactome,STRINGDB
TRAF6
Tbio
Novelty:  0.00109366
Score:  0.995
Data Source:  Reactome,STRINGDB
TBK1
Tchem
Family:  Kinase
Novelty:  0.00194753
Score:  0.993
Data Source:  Reactome,STRINGDB
RIPK1
Tchem
Family:  Kinase
Novelty:  0.00230565
Score:  0.983
Data Source:  Reactome,STRINGDB
IRF3
Tbio
Family:  TF
Novelty:  0.00099474
Score:  0.982
Data Source:  Reactome,STRINGDB
IRF7
Tbio
Family:  TF
Novelty:  0.0021839
Score:  0.975
Data Source:  Reactome,STRINGDB
TANK
Tbio
Novelty:  0.01003866
Score:  0.974
Data Source:  Reactome,STRINGDB
Pathways (818)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (R-HSA-936964)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Reactome
Apoptosis
Reactome
Caspase activation via Death Receptors in the presence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Cytosolic sensors of pathogen-associated DNA
Name
Explore in Pharos
Explore in Source
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Apoptosis
Caspase activation via Death Receptors in the presence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Cytosolic sensors of pathogen-associated DNA
Gene Ontology Terms (37)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
1
1.1
75.3
COVID-19
1
1
0
1.2
56.4
1
1
0
1.3
54.4
1
1
0
1.3
53.7
Agents acting on the renin-angiotensin system use measurement
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
75.3
COVID-19
0
1.2
56.4
0
1.3
54.4
0
1.3
53.7
Agents acting on the renin-angiotensin system use measurement
1
46.9
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
toll like receptor adaptor molecule 1
VGNC:14758
468677
Macaque
toll like receptor adaptor molecule 1
574294
Mouse
MGI:2147032
106759
Dog
toll like receptor adaptor molecule 1
611852
Horse
toll like receptor adaptor molecule 1
VGNC:49344
100062414
Species
Name
OMA
EggNOG
Inparanoid
Chimp
toll like receptor adaptor molecule 1
Macaque
toll like receptor adaptor molecule 1
Mouse
Dog
toll like receptor adaptor molecule 1
Horse
toll like receptor adaptor molecule 1
Publication Statistics
PubMed Score 82.20
PubMed score by year
PubTator Score 190.20
PubTator score by year