Tbio RHPN2 Rhophilin-2

Protein Summary

Description

Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by RefSeq, Apr 2009]

Uniprot Accession IDs

• Q8IUC4
• B2RCG8
• B3KUY8
• B4DUS7
• Q8N3T7
• Q8N9D6
• Q8NE33
• Q96RU1

Gene Name

• RHPN2

Ensembl ID

• ENST00000254260
• ENSP00000254260
• ENSG00000131941

Symbol

• RHOBP
• P76RBE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
PubMedID	0.87
transcription factor binding site profile	0.7
small molecule perturbation	0.63
tissue sample	0.63

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Rhophilin-2

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Rhophilin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.09   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 132   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.09   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0