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Tbio
KRTAP8-1
Keratin-associated protein 8-1

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329621
  • ENSP00000332805
  • ENSG00000183640

Symbol
  • KAP8.1
  • KRTAP8.1
  • KAP8.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.54
tissue
0.47
cell line
0.46
tissue sample
0.37
biological term
0.33


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.39   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.39   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin-associated protein 8-1
745824
Mouse
MGI:1330293
16703
Rat
RGD:2323315
100359826
Dog
keratin associated protein 8-1
VGNC:42543
100687766
Horse
keratin-associated protein 8-1
100064553
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin-associated protein 8-1
Mouse
Rat
Dog
keratin associated protein 8-1
Horse
keratin-associated protein 8-1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IUC2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (40)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (106)
1 – 10 of 106
KRTAP7-1
Tdark
Novelty: 0.31372157
Score: 0.813
Data Source: STRINGDB
KRTAP11-1
Tbio
Novelty: 0.20865014
Score: 0.792
Data Source: STRINGDB
KRTAP24-1
Tdark
Novelty: 0.3470695
Score: 0.774
Data Source: STRINGDB
KRTAP15-1
Tdark
Novelty: 1.11971653
Score: 0.727
Data Source: STRINGDB
KRTAP6-1
Tdark
Novelty: 0.3016588
Score: 0.692
Data Source: STRINGDB
KRTAP19-1
Tdark
Novelty: 8.12369581
Score: 0.664
Data Source: STRINGDB
WFDC13
Tdark
Novelty: 0.32518794
Score: 0.651
Data Source: STRINGDB
KRTAP19-5
Tdark
Novelty: 8.16087009
Score: 0.649
Data Source: STRINGDB
KRTAP19-3
Tdark
Novelty: 1.7849221
Score: 0.648
Data Source: STRINGDB
KRTAP13-1
Tdark
Novelty: 0.47013888
Score: 0.644
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.39

PubMed score by year
PubTator Score  3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer