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Tdark
KRTAP13-1
Keratin-associated protein 13-1

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Hair keratins and hair keratin-associated proteins (KAPs), such as KRTAP13-1, are the main structural proteins of hair fibers (Rogers et al., 2002 [PubMed 12359730]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355459
  • ENSP00000347635
  • ENSG00000198390

Symbol
  • KAP13.1
  • KRTAP13.1
  • KAP13.1
  • KRTAP13.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.49
gene perturbation
0.46
tissue
0.44
cell line
0.4
transcription factor
0.35


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.95   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.95   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (83)
1 – 10 of 83
KRTAP7-1
Tdark
Novelty: 0.31372157
Score: 0.684
Data Source: STRINGDB
KRTAP8-1
Tbio
Novelty: 0.18211237
Score: 0.644
Data Source: STRINGDB
KRTAP9-2
Tdark
Novelty: 0.81609848
Score: 0.62
Data Source: STRINGDB
KRTAP6-2
Tdark
Novelty: 1.37501842
Score: 0.609
Data Source: STRINGDB
KRTAP24-1
Tdark
Novelty: 0.3470695
Score: 0.6
Data Source: STRINGDB
KRTAP20-2
Tdark
Novelty: 1.77962785
Score: 0.599
Data Source: STRINGDB
KRTAP26-1
Tdark
Novelty: 0.48053029
Score: 0.596
Data Source: STRINGDB
KRTAP12-1
Tdark
Novelty: 0.59243755
Score: 0.585
Data Source: STRINGDB
KRTAP12-2
Tdark
Novelty: 94.37239583
Score: 0.582
Data Source: STRINGDB
KRTAP3-1
Tdark
Novelty: 1.73340145
Score: 0.576
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.95

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer