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Tchem
CAMK1D
Calcium/calmodulin-dependent protein kinase type 1D

Protein Summary
Description
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378845
  • ENSP00000368122
  • ENSG00000183049
  • ENST00000619168
  • ENSP00000478874

Symbol
  • CAMKID
  • CKLiK
  • CaM-K1
  • CaMKID
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
transcription factor perturbation
0.88
trait
0.86
transcription factor binding site profile
0.86
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.92   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 404   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.92   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 404   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
bosutinib
chemical structure image
Active Ligands (1)
1 – 1 of 1
CHEMBL388978
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
3
87.1
mathematical ability
1
2
2
82.8
Headache
1
1
1
45.7
body height
2
2
2
37.5
intelligence
1
1
1
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
87.1
mathematical ability
2
82.8
Headache
1
45.7
body height
2
37.5
intelligence
1
25.4
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Aldosterone synthesis and secretion
KEGG
Oxytocin signaling pathway
KEGG
Calcium signaling pathway
KEGG
Glioma
Name
Explore in Pharos
Explore in Source
Aldosterone synthesis and secretion
Oxytocin signaling pathway
Calcium signaling pathway
Glioma
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (126)
1 – 10 of 126
CAMK1
Tchem
Family: Kinase
Novelty: 0.01239891
p_int: 0.999999972
p_ni: 2.8e-8
p_wrong: 1e-9
Score: 0.191
Data Source: BioPlex,STRINGDB
CAMK1G
Tchem
Family: Kinase
Novelty: 0.12524578
p_int: 0.999923361
p_ni: 0.00000293
p_wrong: 0.000073709
Score: 0.536
Data Source: BioPlex,STRINGDB
MUC7
Tbio
Novelty: 0.00750654
p_int: 0.999918014
p_ni: 0.00002396
p_wrong: 0.000058026
Score: 0.217
Data Source: BioPlex,STRINGDB
CKS2
Tbio
Family: Enzyme
Novelty: 0.02482411
p_int: 0.999896638
p_ni: 0.000103358
p_wrong: 5e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
LAMP3
Tbio
Novelty: 0.01677383
p_int: 0.995799658
p_ni: 0.004200267
p_wrong: 7.5e-8
Data Source: BioPlex
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.993138463
p_ni: 0.000934015
p_wrong: 0.005927523
Score: 0.703
Data Source: BioPlex,STRINGDB
CST1
Tbio
Novelty: 0.02399609
p_int: 0.990760901
p_ni: 0.006782805
p_wrong: 0.002456294
Data Source: BioPlex
STPG3
Tdark
Novelty: 1.88764045
p_int: 0.955698732
p_ni: 0.044301249
p_wrong: 2e-8
Score: 0.206
Data Source: BioPlex,STRINGDB
GNRHR
Tclin
Family: GPCR
Novelty: 0.00203671
p_int: 0.954995832
p_ni: 0.044678972
p_wrong: 0.000325195
Score: 0.462
Data Source: BioPlex,STRINGDB
ZG16B
Tbio
Novelty: 0.08792924
p_int: 0.940143927
p_ni: 0.059850149
p_wrong: 0.000005924
Data Source: BioPlex
Publication Statistics
PubMed Score  34.92

PubMed score by year
PubTator Score  15.84

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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