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Tchem
TMPRSS6
Transmembrane protease serine 6

Protein Summary
Description
Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis. The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346753
  • ENSP00000334962
  • ENSG00000187045
  • ENST00000381792
  • ENSP00000371211
  • ENST00000406725
  • ENSP00000385453
  • ENST00000406856
  • ENSP00000384964

Symbol
  • IRIDA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
protein domain
0.97
cell type or tissue
0.76
disease
0.69
biological term
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.03   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.03   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (16)
1 – 10 of 16
CHEMBL3219080
chemical structure image
CHEMBL3219083
chemical structure image
CHEMBL3219085
chemical structure image
CHEMBL3219078
chemical structure image
CHEMBL3219081
chemical structure image
CHEMBL3219086
chemical structure image
CHEMBL3219103
chemical structure image
CHEMBL3219079
chemical structure image
GWAS Traits (44)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
15
8
18
99.8
iron biomarker measurement
8
3
7
4.3
99.8
mean corpuscular hemoglobin
6
4
7
97.1
mean corpuscular volume
9
4
10
97
hematocrit
7
4
8
96.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
18
99.8
iron biomarker measurement
7
4.3
99.8
mean corpuscular hemoglobin
7
97.1
mean corpuscular volume
10
97
hematocrit
8
96.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane serine protease 6
VGNC:53409
458805
Macaque
transmembrane protease, serine 6
696094
Mouse
MGI:1919003
71753
Rat
RGD:1307138
315388
Dog
transmembrane serine protease 6
VGNC:47636
608593
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane serine protease 6
Macaque
transmembrane protease, serine 6
Mouse
Rat
Dog
transmembrane serine protease 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IU80-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Collagen degradation (R-HSA-1442490)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen degradation
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen degradation
Degradation of the extracellular matrix
Extracellular matrix organization
Protein-Protein Interactions (127)
1 – 10 of 127
HJV
Tbio
Novelty: 0.00495995
Score: 0.96
Data Source: STRINGDB
HAMP
Tbio
Novelty: 0.00035828
Score: 0.94
Data Source: STRINGDB
DCN
Tbio
Novelty: 0.00073027
Score: 0.908
Data Source: Reactome,STRINGDB
LAMB3
Tbio
Novelty: 0.00717673
Score: 0.906
Data Source: Reactome,STRINGDB
LAMC2
Tbio
Novelty: 0.00695692
Score: 0.9
Data Source: Reactome,STRINGDB
LAMC1
Tbio
Novelty: 0.01230796
Score: 0.9
Data Source: Reactome,STRINGDB
LAMA5
Tbio
Novelty: 0.02247145
Score: 0.9
Data Source: Reactome,STRINGDB
LAMB1
Tbio
Novelty: 0.0104285
Score: 0.9
Data Source: Reactome,STRINGDB
LAMA3
Tbio
Novelty: 0.00733792
Score: 0.9
Data Source: Reactome,STRINGDB
HFE
Tbio
Novelty: 0.00042077
Score: 0.824
Data Source: STRINGDB
Publication Statistics
PubMed Score  157.03

PubMed score by year
PubTator Score  118.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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