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Tbio
DCP2
m7GpppN-mRNA hydrolase

Protein Summary
Description
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968, PubMed:28002401). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PubMed:28002401). Blocks autophagy in nutrient-rich conditions by repressing the expression o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389063
  • ENSP00000373715
  • ENSG00000172795
  • ENST00000515408
  • ENSP00000425770

Symbol
  • NUDT20
  • NUDT20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.92
virus perturbation
0.88
molecular function
0.84
gene perturbation
0.7
tissue sample
0.68


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.89   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.89   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
decapping mRNA 2
694225
Mouse
MGI:1917890
70640
Rat
RGD:1562909
291604
Dog
decapping mRNA 2
VGNC:39810
489086
Horse
decapping mRNA 2
VGNC:17048
100073182
Species
Name
OMA
EggNOG
Inparanoid
Macaque
decapping mRNA 2
Mouse
Rat
Dog
decapping mRNA 2
Horse
decapping mRNA 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IU60-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
KSRP (KHSRP) binds and destabilizes mRNA
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Deadenylation-dependent mRNA decay
KSRP (KHSRP) binds and destabilizes mRNA
Metabolism of RNA
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred by Curator (IC)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (184)
1 – 10 of 184
DCP1B
Tdark
Novelty: 0.36605365
p_int: 0.999999206
p_ni: 7.94e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
EDC4
Tbio
Novelty: 0.00365253
p_int: 0.999954055
p_ni: 0.000045945
Score: 0.999
Data Source: BioPlex,STRINGDB
EDC3
Tbio
Novelty: 0.02077346
p_int: 0.999785765
p_ni: 0.000214235
Score: 0.999
Data Source: BioPlex,STRINGDB
SPACA1
Tbio
Novelty: 0.07415851
p_int: 0.999648478
p_ni: 0.00035152
p_wrong: 2e-9
Data Source: BioPlex
F9
Tchem
Family: Enzyme
Novelty: 0.00032127
p_int: 0.998073052
p_ni: 0.001926936
p_wrong: 1.2e-8
Data Source: BioPlex
PCBP3
Tbio
Novelty: 0.11681812
p_int: 0.997926719
p_ni: 0.002032279
p_wrong: 0.000041002
Score: 0.282
Data Source: BioPlex,STRINGDB
LY86
Tbio
Novelty: 0.00314575
p_int: 0.995506745
p_ni: 0.004492265
p_wrong: 9.9e-7
Data Source: BioPlex
COLEC10
Tbio
Novelty: 0.02593638
p_int: 0.995120427
p_ni: 0.004251126
p_wrong: 0.000628447
Score: 0.2
Data Source: BioPlex,STRINGDB
LRRC32
Tbio
Novelty: 0.02644086
p_int: 0.994813414
p_ni: 0.004047712
p_wrong: 0.001138874
Score: 0.179
Data Source: BioPlex,STRINGDB
XXYLT1
Tbio
Family: Enzyme
Novelty: 0.16837376
p_int: 0.991784884
p_ni: 0.00821412
p_wrong: 9.96e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  151.89

PubMed score by year
PubTator Score  78.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer