Tbio IFNLR1 Interferon lambda receptor 1

Protein Summary

Description

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8IU57
• Q5VTX5
• Q5VTX7
• Q5VTX8
• Q6ZML8
• Q8IV66
• Q8IZI7
• Q8IZI8
• IFN-lambda receptor 1

Gene Name

• IFNLR1

Ensembl ID

• ENST00000327535
• ENSP00000327824
• ENSG00000185436
• ENST00000327575
• ENSP00000328994
• ENST00000374418
• ENSP00000363539
• ENST00000374421
• ENSP00000363542

Symbol

• IL28RA
• LICR2
• IFNLR
• LICR2
• IL28RA
• CRF2/12
• IL-28R1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.77
tissue sample	0.63
transcription factor	0.59
tissue	0.56
microRNA	0.52

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interferon Lambda Receptor 1

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interferon Lambda Receptor 1

Protein / Defense/immunity Protein / Interferon Lambda Receptor 1

DTO Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interferon Lambda Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.46   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 220   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.46   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0