You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
HIPK1
Homeodomain-interacting protein kinase 1

Protein Summary
Description
Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates home ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340480
  • ENSP00000340956
  • ENSG00000163349
  • ENST00000369553
  • ENSP00000358566
  • ENST00000369558
  • ENSP00000358571
  • ENST00000369559
  • ENSP00000358572
  • ENST00000426820
  • ENSP00000407442

Symbol
  • KIAA0630
  • MYAK
  • NBAK2
  • Myak
  • Nbak2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
small molecule
0.96
transcription factor
0.94
molecular function
0.91
microRNA
0.9


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.67   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.67   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL388978
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
20.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
20.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeodomain interacting protein kinase 1
VGNC:1259
743043
Macaque
homeodomain interacting protein kinase 1
707856
Mouse
MGI:1314873
15257
Rat
RGD:1304941
365895
Dog
homeodomain interacting protein kinase 1
VGNC:41693
475803
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeodomain interacting protein kinase 1
Macaque
homeodomain interacting protein kinase 1
Mouse
Rat
Dog
homeodomain interacting protein kinase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86Z02-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (23)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Muscle contraction
Reactome
Physiological factors
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Gene expression (Transcription)
Generic Transcription Pathway
Muscle contraction
Physiological factors
Gene Ontology Terms (27)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (29)
1 – 10 of 29
FHL3
Tbio
Novelty: 0.11505924
p_int: 0.999948509
p_ni: 5.41e-7
p_wrong: 0.000050951
Score: 0.354
Data Source: BioPlex,STRINGDB
SHARPIN
Tbio
Novelty: 0.0197352
p_int: 0.999659089
p_ni: 0.000019769
p_wrong: 0.000321142
Data Source: BioPlex
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.955
Data Source: Reactome,STRINGDB
DAXX
Tbio
Novelty: 0.00348585
Score: 0.948
Data Source: STRINGDB
NKX2-5
Tbio
Family: TF
Novelty: 0.00125993
Score: 0.943
Data Source: Reactome,STRINGDB
GATA4
Tbio
Family: TF
Novelty: 0.00094282
Score: 0.907
Data Source: Reactome,STRINGDB
NPPA
Tchem
Novelty: 0.00046693
Score: 0.9
Data Source: STRINGDB
RASSF5
Tbio
Novelty: 0.01035881
Score: 0.882
Data Source: STRINGDB
PAGE4
Tbio
Novelty: 0.05404149
Score: 0.841
Data Source: STRINGDB
DCAF7
Tbio
Novelty: 0.02609518
Score: 0.759
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.67

PubMed score by year
PubTator Score  11.21

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: