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Tdark
MED12L
Mediator of RNA polymerase II transcription subunit 12-like protein

Protein Summary
Description
May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309237
  • ENSP00000310760
  • ENSG00000144893
  • ENST00000422248
  • ENSP00000403308
  • ENST00000474524
  • ENSP00000417235

Symbol
  • KIAA1635
  • TNRC11L
  • TRALP
  • TRALPUSH
  • NOPAR
  • TRALP
  • TNRC11L
  • TRALPUSH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
interacting protein
0.89
microRNA
0.68
cell line
0.67
transcription factor binding site profile
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.17   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 21   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.17   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
82.9
smoking status measurement
1
1
1
75.8
myeloid white cell count
1
1
1
75.4
eosinophil count
2
1
2
59.3
insomnia measurement
1
1
0
1
55.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
82.9
smoking status measurement
1
75.8
myeloid white cell count
1
75.4
eosinophil count
2
59.3
insomnia measurement
0
1
55.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 12 like
VGNC:2043
460784
Macaque
mediator complex subunit 12 like
709571
Mouse
MGI:2139916
329650
Dog
mediator complex subunit 12 like
VGNC:43121
100683791
Horse
mediator complex subunit 12 like
VGNC:20071
100056881
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 12 like
Macaque
mediator complex subunit 12 like
Mouse
Dog
mediator complex subunit 12 like
Horse
mediator complex subunit 12 like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86YW9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (63)
1 – 10 of 63
MED19
Tbio
Family: Enzyme
Novelty: 0.03926689
p_int: 0.999999932
p_ni: 6.7e-8
p_wrong: 2e-9
Score: 0.959
Data Source: BioPlex,STRINGDB
MED21
Tbio
Family: Enzyme
Novelty: 0.06996616
p_int: 0.999999867
p_ni: 1.32e-7
p_wrong: 1e-9
Score: 0.909
Data Source: BioPlex,STRINGDB
MED17
Tbio
Family: Enzyme
Novelty: 0.02984503
p_int: 0.999999695
p_ni: 3.05e-7
Score: 0.855
Data Source: BioPlex,STRINGDB
CCNC
Tbio
Novelty: 0.00585842
p_int: 0.999999634
p_ni: 3.66e-7
Score: 0.979
Data Source: BioPlex,STRINGDB
MED18
Tbio
Family: Enzyme
Novelty: 0.04066825
p_int: 0.999999563
p_ni: 4.37e-7
Score: 0.96
Data Source: BioPlex,STRINGDB
MED10
Tdark
Family: Enzyme
Novelty: 0.02988632
p_int: 0.999999464
p_ni: 5.34e-7
p_wrong: 2e-9
Score: 0.679
Data Source: BioPlex,STRINGDB
MED4
Tbio
Family: Enzyme
Novelty: 0.01200585
p_int: 0.999999261
p_ni: 7.38e-7
Score: 0.83
Data Source: BioPlex,STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
p_int: 0.999998897
p_ni: 0.000001101
p_wrong: 2e-9
Score: 0.978
Data Source: BioPlex,STRINGDB
MED20
Tbio
Family: Enzyme
Novelty: 0.02039559
p_int: 0.999997609
p_ni: 0.000002317
p_wrong: 7.4e-8
Score: 0.711
Data Source: BioPlex,STRINGDB
MED28
Tbio
Family: Enzyme
Novelty: 0.00362108
p_int: 0.999977728
p_ni: 0.00002227
p_wrong: 2e-9
Score: 0.681
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  9.17

PubMed score by year
PubTator Score  2.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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