Tbio GPHB5 Glycoprotein hormone beta-5

Protein Summary

Description

Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q86YW7
• Q6NTD0
• Q8NFW2

Gene Name

• GPHB5

Ensembl ID

• ENST00000314140
• ENSP00000479431
• ENSG00000179600
• ENST00000621500
• ENSP00000478993

Symbol

• GPB5
• ZLUT1
• B5
• GPB5
• ZLUT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.65
metabolite	0.45
cell line	0.42
protein domain	0.41
tissue sample	0.4

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Glycoprotein Hormone Beta-5

DTO Classes

Protein / Signaling / Hormone / Glycoprotein Hormone Beta-5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.46   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 60   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.46   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0