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Tbio
TREML1
Trem-like transcript 1 protein

Protein Summary
Description
Cell surface receptor that may play a role in the innate and adaptive immune response. This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373127
  • ENSP00000362219
  • ENSG00000161911
  • ENST00000426005
  • ENSP00000402855
  • ENST00000437044
  • ENSP00000400405

Symbol
  • TLT1
  • TLT1
  • TLT-1
  • PRO3438
  • GLTL1825
  • dJ238O23.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.57
tissue sample
0.56
cell line
0.51
cell type or tissue
0.46
protein domain
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.53   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.53   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
TREML2
Tbio
Novelty:  0.05038302
Score:  0.913
Data Source:  STRINGDB
TREM1
Tbio
Novelty:  0.00249253
Score:  0.805
Data Source:  STRINGDB
TREM2
Tbio
Novelty:  0.00228007
Score:  0.77
Data Source:  STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.706
Data Source:  STRINGDB
SELP
Tclin
Novelty:  0.00019779
Score:  0.693
Data Source:  STRINGDB
TREML4
Tbio
Novelty:  0.15519748
Score:  0.668
Data Source:  STRINGDB
EPHX4
Tbio
Family:  Enzyme
Novelty:  0.08951991
Score:  0.65
Data Source:  STRINGDB
MPIG6B
Tbio
Novelty:  0.04808462
Score:  0.649
Data Source:  STRINGDB
FCER1A
Tbio
Novelty:  0.00362182
Score:  0.628
Data Source:  STRINGDB
CD300LB
Tbio
Novelty:  0.10587821
Score:  0.615
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
late-onset Alzheimers disease
2
3
0
1.7
90.5
monocyte count
2
2
2
87.7
leukocyte count
2
2
2
76.2
2
2
0
4.2
66.6
mean corpuscular volume
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
late-onset Alzheimers disease
0
1.7
90.5
monocyte count
2
87.7
leukocyte count
2
76.2
0
4.2
66.6
mean corpuscular volume
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
triggering receptor expressed on myeloid cells like 1
VGNC:3770
748461
Macaque
triggering receptor expressed on myeloid cells like 1
719732
Mouse
MGI:1918576
71326
Dog
triggering receptor expressed on myeloid cells like 1 [Source:HGNC Symbol;Acc:HGNC:20434]
Horse
triggering receptor expressed on myeloid cells like 1
VGNC:24483
100066151
Species
Name
OMA
EggNOG
Inparanoid
Chimp
triggering receptor expressed on myeloid cells like 1
Macaque
triggering receptor expressed on myeloid cells like 1
Mouse
Dog
triggering receptor expressed on myeloid cells like 1 [Source:HGNC Symbol;Acc:HGNC:20434]
Horse
triggering receptor expressed on myeloid cells like 1
Publication Statistics
PubMed Score 32.53
PubMed score by year
PubTator Score 12.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title