Tbio TREML1 Trem-like transcript 1 protein

Protein Summary

Description

Cell surface receptor that may play a role in the innate and adaptive immune response. This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• Q86YW5
• Q496B3
• Q8IWY1
• Q8IWY2
• TLT-1

Gene Name

• TREML1

Ensembl ID

• ENST00000373127
• ENSP00000362219
• ENSG00000161911
• ENST00000426005
• ENSP00000402855
• ENST00000437044
• ENSP00000400405

Symbol

• TLT1
• TLT1
• TLT-1
• PRO3438
• GLTL1825
• dJ238O23.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.57
tissue sample	0.56
cell line	0.51
cell type or tissue	0.46
protein domain	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.36   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 268   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.36   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0