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Tbio
PLCZ1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

Protein Classes
Protein Summary
Description
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisph ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266505
  • ENSP00000266505
  • ENSG00000139151
  • ENST00000539875
  • ENSP00000445026

Symbol
  • SPGF17
  • PLCzeta
  • NYD-SP27
  • PLC-zeta-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
metabolite
0.89
gene perturbation
0.85
virus perturbation
0.68
pathway
0.63


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.66   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.66   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase C zeta 1
VGNC:5536
743002
Macaque
phospholipase C zeta 1
703293
Mouse
MGI:2150308
114875
Rat
RGD:1359567
497197
Dog
phospholipase C zeta 1
VGNC:44659
486657
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase C zeta 1
Macaque
phospholipase C zeta 1
Mouse
Rat
Dog
phospholipase C zeta 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86YW0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (126)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IP3 and IP4 in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IP3 and IP4 in the cytosol
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (143)
1 – 10 of 143
SEMG1
Tbio
Novelty: 0.0161449
p_int: 0.998666785
p_ni: 0.001333215
p_wrong: 1e-9
Score: 0.303
Data Source: BioPlex,STRINGDB
KLK7
Tchem
Family: Enzyme
Novelty: 0.00757766
p_int: 0.996885805
p_ni: 0.003105448
p_wrong: 0.000008747
Score: 0.211
Data Source: BioPlex,STRINGDB
SERPINA12
Tbio
Novelty: 0.00549132
p_int: 0.969580907
p_ni: 0.030419092
p_wrong: 1e-9
Score: 0.209
Data Source: BioPlex,STRINGDB
CST6
Tbio
Novelty: 0.02811473
p_int: 0.898288183
p_ni: 0.100910274
p_wrong: 0.000801542
Score: 0.221
Data Source: BioPlex,STRINGDB
ECM1
Tbio
Novelty: 0.00518679
p_int: 0.80875031
p_ni: 0.19124967
p_wrong: 2e-8
Score: 0.19
Data Source: BioPlex,STRINGDB
HAL
Tbio
Family: Enzyme
Novelty: 0.01504631
p_int: 0.759321549
p_ni: 0.240678451
Score: 0.196
Data Source: BioPlex,STRINGDB
PIP5KL1
Tbio
Family: Enzyme
Novelty: 0.15208771
Score: 0.947
Data Source: STRINGDB
ITPR1
Tchem
Family: IC
Novelty: 0.00111834
Score: 0.936
Data Source: STRINGDB
PIP5K1B
Tbio
Family: Kinase
Novelty: 0.05013433
Score: 0.928
Data Source: STRINGDB
PIP5K1A
Tbio
Family: Kinase
Novelty: 0.05039085
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score  186.66

PubMed score by year
PubTator Score  43.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer