Tbio PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

Protein Summary

Description

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• Q86YW0
• Q08AQ7
• Q96J70

Gene Name

• PLCZ1

Ensembl ID

• ENST00000266505
• ENSP00000266505
• ENSG00000139151
• ENST00000539875
• ENSP00000445026

Symbol

• SPGF17
• PLCzeta
• NYD-SP27
• PLC-zeta-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
metabolite	0.89
gene perturbation	0.85
virus perturbation	0.68
pathway	0.63

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Zeta-1

Protein / Hydrolase / Lipase / Phospholipase / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Zeta-1

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Zeta-1

Protein / Calcium-binding Protein / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Zeta-1

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Zeta-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 214.2   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 110   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 214.2   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0