Tbio MIB1 E3 ubiquitin-protein ligase MIB1

Protein Summary

Description

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• Q86YT6
• B0YJ38
• Q2TB37
• Q68D01
• Q6YI51
• Q8NBY0
• Q8TCB5
• Q8TCL7
• Q9P2M3

Gene Name

• MIB1

Ensembl ID

• ENST00000261537
• ENSP00000261537
• ENSG00000101752

Symbol

• DIP1
• KIAA1323
• ZZANK2
• MIB
• DIP1
• ZZZ6
• DIP-1
• LVNC7
• ZZANK2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.96
virus perturbation	0.92
protein domain	0.85
transcription factor perturbation	0.84
histone modification site profile	0.8

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Mib1

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Mib1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.41   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 307   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.41   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0