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Tbio
MIB1
E3 ubiquitin-protein ligase MIB1

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261537
  • ENSP00000261537
  • ENSG00000101752

Symbol
  • DIP1
  • KIAA1323
  • ZZANK2
  • MIB
  • DIP1
  • ZZZ6
  • DIP-1
  • LVNC7
  • ZZANK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.96
virus perturbation
0.92
protein domain
0.85
transcription factor perturbation
0.84
histone modification site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.84   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 307   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.84   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (135)
OTUD3
Tbio
Novelty:  0.11839931
p_int:  0.999198097
p_ni:  0.000801903
Data Source:  BioPlex
PCM1
Tbio
Novelty:  0.02901589
p_int:  0.999039008
p_ni:  0.000960992
Score:  0.547
Data Source:  BioPlex,STRINGDB
LRRCC1
Tdark
Novelty:  0.14730953
p_int:  0.994596927
p_ni:  0.005403073
Score:  0.214
Data Source:  BioPlex,STRINGDB
CHRNA3
Tclin
Family:  IC
Novelty:  0.00659767
p_int:  0.962621648
p_ni:  0.037378352
Score:  0.185
Data Source:  BioPlex,STRINGDB
ARHGEF7
Tbio
Novelty:  0.00919946
p_int:  0.942237838
p_ni:  0.057762162
Data Source:  BioPlex
FSD1
Tbio
Novelty:  0.03452477
p_int:  0.875595691
p_ni:  0.124404309
Score:  0.319
Data Source:  BioPlex,STRINGDB
GRIN2A
Tclin
Family:  IC
Novelty:  0.00060035
p_int:  0.869332973
p_ni:  0.130667027
Score:  0.168
Data Source:  BioPlex,STRINGDB
FAM171B
Tdark
Novelty:  0.38456365
p_int:  0.863792393
p_ni:  0.136207607
Score:  0.187
Data Source:  BioPlex,STRINGDB
ANKRD55
Tbio
Novelty:  0.09730833
p_int:  0.854348401
p_ni:  0.145651599
Score:  0.188
Data Source:  BioPlex,STRINGDB
RNF10
Tbio
Novelty:  0.09086567
p_int:  0.824286167
p_ni:  0.175713833
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

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Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Constitutive Signaling by NOTCH1 HD Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
45.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
45.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2443157
225164
Rat
RGD:1307195
307594
Dog
mindbomb E3 ubiquitin protein ligase 1
VGNC:43217
490521
Horse
mindbomb E3 ubiquitin protein ligase 1
VGNC:20169
100060229
Cow
mindbomb E3 ubiquitin protein ligase 1
VGNC:31455
533735
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
mindbomb E3 ubiquitin protein ligase 1
Horse
mindbomb E3 ubiquitin protein ligase 1
Cow
mindbomb E3 ubiquitin protein ligase 1
Publication Statistics
PubMed Score 18.84
PubMed score by year
PubTator Score 2485.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title