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Tchem
SLC13A5
Solute carrier family 13 member 5

Protein Summary
Description
High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol. This gene encodes a protein belonging to the solute carrier family 13 group of proteins. This family member is a sodium-dependent citrate cotransporter that may regulate metabolic processes. Mutations in this gene cause early infantile epileptic encephalopathy 25. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293800
  • ENSP00000293800
  • ENSG00000141485
  • ENST00000381074
  • ENSP00000370464
  • ENST00000433363
  • ENSP00000406220
  • ENST00000573648
  • ENSP00000459372

Symbol
  • NACT
  • INDY
  • NACT
  • mIndy
  • EIEE25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
cell type or tissue
0.59
gene perturbation
0.53
microRNA
0.5
tissue sample
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.83   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.83   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (8)
CHEMBL3771175
Rendered image for CHEMBL3771175
CHEMBL3770609
Rendered image for CHEMBL3770609
CHEMBL3770497
Rendered image for CHEMBL3770497
CHEMBL3770370
Rendered image for CHEMBL3770370
CHEMBL3770675
Rendered image for CHEMBL3770675
CHEMBL3771118
Rendered image for CHEMBL3771118
Protein-Protein Interactions (31)
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.877315845
p_ni:  0.122684154
Score:  0.302
Data Source:  BioPlex,STRINGDB
SLC15A5
Tdark
Family:  Transporter
Novelty:  0.59784242
Score:  0.925
Data Source:  STRINGDB
PITPNM3
Tbio
Novelty:  0.02122312
Score:  0.663
Data Source:  STRINGDB
DYRK1A
Tchem
Family:  Kinase
Novelty:  0.00226963
Score:  0.556
Data Source:  STRINGDB
IGFBP1
Tchem
Novelty:  0.0006975
Score:  0.556
Data Source:  STRINGDB
DYRK1B
Tchem
Family:  Kinase
Novelty:  0.01960932
Score:  0.55
Data Source:  STRINGDB
SLC25A1
Tbio
Family:  Transporter
Novelty:  0.00547533
Score:  0.537
Data Source:  STRINGDB
FAM208B
Tdark
Novelty:  1.21420488
Score:  0.536
Data Source:  STRINGDB
SLC5A6
Tbio
Family:  Transporter
Novelty:  0.0126926
Score:  0.533
Data Source:  STRINGDB
ZNF540
Tbio
Family:  TF
Novelty:  0.42941109
Score:  0.533
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Sodium-coupled sulphate, di- and tri-carboxylate transporters
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Sodium-coupled sulphate, di- and tri-carboxylate transporters
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
3
3
85.6
amino acid measurement
1
1
1
69.5
protein measurement
1
1
1
69.5
testosterone measurement
1
1
1
50.6
calcium measurement
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
85.6
amino acid measurement
1
69.5
protein measurement
1
69.5
testosterone measurement
1
50.6
calcium measurement
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 13 member 5
VGNC:9614
455245
Macaque
solute carrier family 13 member 5
713292
Mouse
MGI:3037150
237831
Rat
RGD:631374
266998
Dog
solute carrier family 13 member 5
VGNC:46231
606984
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 13 member 5
Macaque
solute carrier family 13 member 5
Mouse
Rat
Dog
solute carrier family 13 member 5
Publication Statistics
PubMed Score 163.83
PubMed score by year
PubTator Score 116.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title