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Tbio
RAB43
Ras-related protein Rab-43

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315150
  • ENSP00000319781
  • ENSG00000172780
  • ENST00000393304
  • ENSP00000376981
  • ENST00000393305
  • ENSP00000376982
  • ENST00000393307
  • ENSP00000376984
  • ENST00000393308
  • ENSP00000376985
  • ENST00000476465
  • ENSP00000427632
  • ENST00000615093
  • ENSP00000481399

Symbol
  • RAB41
  • RAB41
  • RAB11B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
molecular function
0.91
interacting protein
0.85
transcription factor binding site profile
0.71
cellular component
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.99   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.99   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Metabolism of proteins
Post-translational protein modification
RAB geranylgeranylation
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (141)
1 – 10 of 141
WHAMM
Tbio
Novelty: 0.06965013
p_int: 0.999999773
p_ni: 2.18e-7
p_wrong: 9e-9
Data Source: BioPlex
LHFPL2
Tdark
Novelty: 0.85421144
p_int: 0.999995867
p_ni: 0.000004131
p_wrong: 2e-9
Data Source: BioPlex
C7orf43
Tdark
Novelty: 1.11975505
p_int: 0.999985508
p_ni: 0.000014491
Data Source: BioPlex
CHML
Tbio
Family: Enzyme
Novelty: 0.00509709
p_int: 0.999980539
p_ni: 0.000019461
Score: 0.935
Data Source: BioPlex,STRINGDB
TRAPPC9
Tbio
Novelty: 0.02703008
p_int: 0.999953782
p_ni: 0.000046218
Score: 0.384
Data Source: BioPlex,STRINGDB
GDI2
Tbio
Novelty: 0.02861013
p_int: 0.999921328
p_ni: 0.000078673
Score: 0.42
Data Source: BioPlex,STRINGDB
HEATR5B
Tdark
Novelty: 3.21111035
p_int: 0.999763209
p_ni: 0.000236733
p_wrong: 5.8e-8
Data Source: BioPlex
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
p_int: 0.999698326
p_ni: 0.000301607
p_wrong: 6.8e-8
Score: 0.933
Data Source: BioPlex,STRINGDB
NBN
Tbio
Novelty: 0.00759456
p_int: 0.999691176
p_ni: 0.00030702
p_wrong: 0.000001804
Data Source: BioPlex
CLEC16A
Tbio
Novelty: 0.0212098
p_int: 0.999667183
p_ni: 0.000102371
p_wrong: 0.000230446
Data Source: BioPlex
Publication Statistics
PubMed Score  9.99

PubMed score by year
PubTator Score  4.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer