Tbio RAB43 Ras-related protein Rab-43

Protein Summary

Description

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

Uniprot Accession IDs

• Q86YS6
• A8K4P9
• E9PBQ0

Gene Name

• RAB43

Ensembl ID

• ENST00000315150
• ENSP00000319781
• ENSG00000172780
• ENST00000393304
• ENSP00000376981
• ENST00000393305
• ENSP00000376982
• ENST00000393307
• ENSP00000376984
• ENST00000393308
• ENSP00000376985
• ENST00000476465
• ENSP00000427632
• ENST00000615093
• ENSP00000481399

Symbol

• RAB41
• RAB41
• RAB11B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
molecular function	0.91
interacting protein	0.85
transcription factor binding site profile	0.71
cellular component	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.61   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.61   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0