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Tbio
GPSM1
G-protein-signaling modulator 1

Protein Summary
Description
Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291775
  • ENSP00000291775
  • ENSG00000160360
  • ENST00000392944
  • ENSP00000376673
  • ENST00000429455
  • ENSP00000390705

Symbol
  • AGS3
  • AGS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor
0.74
histone modification site profile
0.73
tissue
0.61
cellular component
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.21   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.21   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (277)
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.999999766
p_ni:  1.38e-7
p_wrong:  9.6e-8
Data Source:  BioPlex
UGP2
Tbio
Family:  Enzyme
Novelty:  0.00760963
p_int:  0.999999612
p_ni:  3.88e-7
Score:  0.239
Data Source:  BioPlex,STRINGDB
BRD4
Tchem
Family:  Epigenetic
Novelty:  0.0013933
p_int:  0.99999951
p_ni:  4.89e-7
p_wrong:  1e-9
Score:  0.301
Data Source:  BioPlex,STRINGDB
SAPCD2
Tbio
Novelty:  0.06798955
p_int:  0.999999351
p_ni:  6.49e-7
Score:  0.28
Data Source:  BioPlex,STRINGDB
GNAI3
Tbio
Novelty:  0.03484857
p_int:  0.999999175
p_ni:  7.97e-7
p_wrong:  2.7e-8
Score:  0.984
Data Source:  BioPlex,STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
p_int:  0.999509008
p_ni:  0.000002631
p_wrong:  0.000488361
Score:  0.99
Data Source:  BioPlex,STRINGDB
NUMA1
Tbio
Novelty:  0.00158543
p_int:  0.996937927
p_ni:  0.003062073
Score:  0.921
Data Source:  BioPlex,STRINGDB
KLHL18
Tdark
Novelty:  0.52915213
p_int:  0.985801541
p_ni:  0.00453646
p_wrong:  0.009661999
Score:  0.209
Data Source:  BioPlex,STRINGDB
DACH1
Tbio
Novelty:  0.00986576
p_int:  0.985624095
p_ni:  0.000546771
p_wrong:  0.013829134
Score:  0.691
Data Source:  BioPlex,STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (38)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
14
10
4
1.1
98.8
3
3
1
1.2
94.9
HbA1c measurement
3
3
3
94.5
leukocyte count
3
3
3
92.1
4
3
1
1.1
91.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
98.8
1
1.2
94.9
HbA1c measurement
3
94.5
leukocyte count
3
92.1
1
1.1
91.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein signaling modulator 1
VGNC:8891
464915
Macaque
G protein signaling modulator 1
710652
Mouse
MGI:1915089
67839
Rat
RGD:628682
246254
Dog
G protein signaling modulator 1
VGNC:41457
100855572
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein signaling modulator 1
Macaque
G protein signaling modulator 1
Mouse
Rat
Dog
G protein signaling modulator 1
Publication Statistics
PubMed Score 39.21
PubMed score by year
PubTator Score 34.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title