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Tbio
CPNE8
Copine-8

Protein Summary
Description
Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331366
  • ENSP00000329748
  • ENSG00000139117
  • ENST00000538596
  • ENSP00000439237
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
histone modification site profile
0.82
transcription factor perturbation
0.74
phenotype
0.69
microRNA
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.02   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.02   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
TMEM185A
Tdark
Novelty:  0.0262898
p_int:  0.968222411
p_ni:  0.031777589
Score:  0.187
Data Source:  BioPlex,STRINGDB
CSPP1
Tbio
Novelty:  0.02734691
p_int:  0.800246473
p_ni:  0.199753527
Score:  0.221
Data Source:  BioPlex,STRINGDB
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.780908625
p_ni:  0.219091375
Score:  0.185
Data Source:  BioPlex,STRINGDB
SYT10
Tbio
Novelty:  0.03869283
Score:  0.675
Data Source:  STRINGDB
ADAM7
Tbio
Family:  Enzyme
Novelty:  0.02387438
Score:  0.613
Data Source:  STRINGDB
C12orf4
Tdark
Novelty:  0.35695485
Score:  0.61
Data Source:  STRINGDB
CPED1
Tdark
Family:  Enzyme
Novelty:  0.13549237
Score:  0.607
Data Source:  STRINGDB
ITFG2
Tbio
Novelty:  0.41720651
Score:  0.594
Data Source:  STRINGDB
RCHY1
Tbio
Novelty:  0.01853663
Score:  0.593
Data Source:  STRINGDB
SLF1
Tbio
Novelty:  0.04904367
Score:  0.585
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
5
1
1.1
95.3
smoking status measurement
1
1
1
49.5
heart rate
1
1
1
30.2
alcohol consumption measurement
1
1
1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1.1
95.3
smoking status measurement
1
49.5
heart rate
1
30.2
alcohol consumption measurement
1
1.5
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
copine 8
VGNC:8383
465378
Macaque
copine 8
696586
Mouse
MGI:1914121
66871
Rat
RGD:1307939
362988
Dog
copine 8
VGNC:39567
477646
Species
Name
OMA
EggNOG
Inparanoid
Chimp
copine 8
Macaque
copine 8
Mouse
Rat
Dog
copine 8
Publication Statistics
PubMed Score 8.02
PubMed score by year
PubTator Score 3.58
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title