Tbio CPNE8 Copine-8

Protein Summary

Description

Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q86YQ8
• Q2TB41
• Q86VY2

Gene Name

• CPNE8

Ensembl ID

• ENST00000331366
• ENSP00000329748
• ENSG00000139117
• ENST00000538596
• ENSP00000439237

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.83
histone modification site profile	0.82
transcription factor perturbation	0.74
phenotype	0.69
microRNA	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.02   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.02   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (35)

Explore Interacting Targets

1 – 10 of 35

• See Interactions on String-DB

TMEM185A

Tdark

Novelty:  0.0262898

p_int:  0.968222411

p_ni:  0.031777589

Score:  0.187

Data Source:  BioPlex,STRINGDB

CSPP1

Tbio

Novelty:  0.02734691

p_int:  0.800246473

p_ni:  0.199753527

Score:  0.221

Data Source:  BioPlex,STRINGDB

SLC25A41

Tdark

Family:  Transporter

Novelty:  1.04918395

p_int:  0.780908625

p_ni:  0.219091375

Score:  0.185

Data Source:  BioPlex,STRINGDB

SYT10

Tbio

Novelty:  0.03869283

Score:  0.675

Data Source:  STRINGDB

ADAM7

Tbio

Family:  Enzyme

Novelty:  0.02387438

Score:  0.613

Data Source:  STRINGDB

C12orf4

Tdark

Novelty:  0.35695485

Score:  0.61

Data Source:  STRINGDB

CPED1

Tdark

Family:  Enzyme

Novelty:  0.13549237

Score:  0.607

Data Source:  STRINGDB

ITFG2

Tbio

Novelty:  0.41720651

Score:  0.594

Data Source:  STRINGDB

RCHY1

Tbio

Novelty:  0.01853663

Score:  0.593

Data Source:  STRINGDB

SLF1

Tbio

Novelty:  0.04904367

Score:  0.585

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (1)

Components (2)

Processes (1)

Find Similar Targets

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
calcium-dependent phospholipid binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	2	5	1	1.1	95.3
smoking status measurement	EFO_0006527	1	1	1		49.5
heart rate	EFO_0004326	1	1	1		30.2
alcohol consumption measurement	EFO_0007878	1	1	1		1.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	1	1.1	95.3
smoking status measurement	EFO_0006527	1		49.5
heart rate	EFO_0004326	1		30.2
alcohol consumption measurement	EFO_0007878	1		1.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Phosphoprotein
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
alcohol consumption measurement
chronotype measurement
heart rate
smoking status measurement

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	copine 8	VGNC:8383	465378
Macaque	copine 8		696586
Mouse	copine VIII	MGI:1914121	66871
Rat	copine 8	RGD:1307939	362988
Dog	copine 8	VGNC:39567	477646

Species	Name	OMA	EggNOG	Inparanoid
Chimp	copine 8
Macaque	copine 8
Mouse	copine VIII
Rat	copine 8
Dog	copine 8

Publication Statistics

PubMed Score 8.02

PubMed score by year

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PubTator Score 3.58

PubTator score by year

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Related Publications

Text Mined References (16)

Items per page:

10

0 of 0

PMID	Year	Title