Tbio GATAD2A Transcriptional repressor p66-alpha

Protein Summary

Description

Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B.

Uniprot Accession IDs

• Q86YP4
• B5MC40
• Q7L3J2
• Q96F28
• Q9NPU2
• Q9NXS1
• Hp66alpha

Gene Name

• GATAD2A

Ensembl ID

• ENST00000358713
• ENSP00000351552
• ENSG00000167491
• ENST00000360315
• ENSP00000353463
• ENST00000404158
• ENSP00000384899

Symbol

• p66alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
disease perturbation	0.97
transcription factor binding site profile	0.9
kinase perturbation	0.88
virus perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Transcriptional Repressor P66-alpha

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Transcriptional Repressor P66-alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.03   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 203   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.03   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0