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Tbio
GATAD2A
Transcriptional repressor p66-alpha

Protein Summary
Description
Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358713
  • ENSP00000351552
  • ENSG00000167491
  • ENST00000360315
  • ENSP00000353463
  • ENST00000404158
  • ENSP00000384899

Symbol
  • p66alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
disease perturbation
0.97
transcription factor binding site profile
0.9
kinase perturbation
0.88
virus perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.2   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.2   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
83.9
body height
2
2
2
73.9
refractive error measurement
2
2
1
6.1
69.4
1
1
1
58.2
prostate carcinoma
1
1
1
58.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
83.9
body height
2
73.9
refractive error measurement
1
6.1
69.4
1
58.2
prostate carcinoma
1
58.2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Protein-Protein Interactions (188)
1 – 10 of 188
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.999999969
p_ni: 3.1e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
CHD5
Tbio
Family: Epigenetic
Novelty: 0.06408395
p_int: 0.999999969
p_ni: 3.1e-8
Score: 0.969
Data Source: BioPlex,STRINGDB
MBD3L1
Tbio
Novelty: 0.11297566
p_int: 0.999999596
p_ni: 4.04e-7
Score: 0.92
Data Source: BioPlex,STRINGDB
RBBP7
Tbio
Novelty: 0.01795364
p_int: 0.999999477
p_ni: 5.23e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
ZNF219
Tbio
Family: TF
Novelty: 0.17515242
p_int: 0.999999192
p_ni: 8.08e-7
Score: 0.846
Data Source: BioPlex,STRINGDB
CHD3
Tbio
Family: Epigenetic
Novelty: 0.00657278
p_int: 0.999997396
p_ni: 0.000002603
Score: 0.998
Data Source: BioPlex,STRINGDB
ZMYND8
Tbio
Family: Epigenetic
Novelty: 0.05352096
p_int: 0.999996614
p_ni: 0.000003386
Score: 0.725
Data Source: BioPlex,STRINGDB
ZNF592
Tbio
Novelty: 0.12109299
p_int: 0.999994453
p_ni: 0.000005547
Score: 0.591
Data Source: BioPlex,STRINGDB
MBD2
Tchem
Family: TF
Novelty: 0.01209635
p_int: 0.999991142
p_ni: 0.000008824
p_wrong: 3.3e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
MTA3
Tbio
Family: TF
Novelty: 0.02667635
p_int: 0.999990027
p_ni: 0.000009973
Score: 0.995
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  18.20

PubMed score by year
PubTator Score  5.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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