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Tbio
GATAD2A
Transcriptional repressor p66-alpha

Protein Summary
Description
Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358713
  • ENSP00000351552
  • ENSG00000167491
  • ENST00000360315
  • ENSP00000353463
  • ENST00000404158
  • ENSP00000384899

Symbol
  • p66alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
disease perturbation
0.97
transcription factor binding site profile
0.9
kinase perturbation
0.88
virus perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.2   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.2   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
83.9
body height
2
2
2
73.9
refractive error measurement
2
2
1
6.1
69.4
1
1
1
58.2
prostate carcinoma
1
1
1
58.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
83.9
body height
2
73.9
refractive error measurement
1
6.1
69.4
1
58.2
prostate carcinoma
1
58.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GATA zinc finger domain containing 2A
VGNC:2398
455876
Mouse
MGI:2384585
234366
Rat
RGD:1310596
290669
Dog
GATA zinc finger domain containing 2A
VGNC:41126
484806
Horse
GATA zinc finger domain containing 2A
VGNC:18257
100071147
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GATA zinc finger domain containing 2A
Mouse
Rat
Dog
GATA zinc finger domain containing 2A
Horse
GATA zinc finger domain containing 2A
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86YP4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Protein-Protein Interactions (188)
1 – 10 of 188
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.999999969
p_ni: 3.1e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
CHD5
Tbio
Family: Epigenetic
Novelty: 0.06408395
p_int: 0.999999969
p_ni: 3.1e-8
Score: 0.969
Data Source: BioPlex,STRINGDB
MBD3L1
Tbio
Novelty: 0.11297566
p_int: 0.999999596
p_ni: 4.04e-7
Score: 0.92
Data Source: BioPlex,STRINGDB
RBBP7
Tbio
Novelty: 0.01795364
p_int: 0.999999477
p_ni: 5.23e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
ZNF219
Tbio
Family: TF
Novelty: 0.17515242
p_int: 0.999999192
p_ni: 8.08e-7
Score: 0.846
Data Source: BioPlex,STRINGDB
CHD3
Tbio
Family: Epigenetic
Novelty: 0.00657278
p_int: 0.999997396
p_ni: 0.000002603
Score: 0.998
Data Source: BioPlex,STRINGDB
ZMYND8
Tbio
Family: Epigenetic
Novelty: 0.05352096
p_int: 0.999996614
p_ni: 0.000003386
Score: 0.725
Data Source: BioPlex,STRINGDB
ZNF592
Tbio
Novelty: 0.12109299
p_int: 0.999994453
p_ni: 0.000005547
Score: 0.591
Data Source: BioPlex,STRINGDB
MBD2
Tchem
Family: TF
Novelty: 0.01209635
p_int: 0.999991142
p_ni: 0.000008824
p_wrong: 3.3e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
MTA3
Tbio
Family: TF
Novelty: 0.02667635
p_int: 0.999990027
p_ni: 0.000009973
Score: 0.995
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  18.20

PubMed score by year
PubTator Score  5.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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