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Tbio
PPARGC1B
Peroxisome proliferator-activated receptor gamma coactivator 1-beta

Protein Summary
Description
Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in pred ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309241
  • ENSP00000312649
  • ENSG00000155846
  • ENST00000360453
  • ENSP00000353638
  • ENST00000394320
  • ENSP00000377855
  • ENST00000403750
  • ENSP00000384403

Symbol
  • PERC
  • PGC1
  • PGC1B
  • PPARGC1
  • PERC
  • ERRL1
  • PGC1B
  • PGC-1(beta)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
molecular function
0.9
transcription factor
0.85
transcription factor perturbation
0.8
transcription factor binding site profile
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.2   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.2   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
freckles
1
1
0
1.4
71.4
solar lentigines measurement
1
1
0
1.3
61.9
1
1
0
1.1
57.7
suntan
1
1
1
39.3
keratinocyte carcinoma
1
1
0
1.1
24.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
freckles
0
1.4
71.4
solar lentigines measurement
0
1.3
61.9
0
1.1
57.7
suntan
1
39.3
keratinocyte carcinoma
0
1.1
24.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PPARG coactivator 1 beta
VGNC:7108
471692
Macaque
PPARG coactivator 1 beta
711027
Mouse
MGI:2444934
170826
Rat
RGD:727948
291567
Dog
PPARG coactivator 1 beta
VGNC:44838
489190
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PPARG coactivator 1 beta
Macaque
PPARG coactivator 1 beta
Mouse
Rat
Dog
PPARG coactivator 1 beta
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Mitochondrial biogenesis
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Mitochondrial biogenesis
Gene Ontology Terms (27)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (95)
1 – 10 of 95
PNKD
Tbio
Family: Enzyme
Novelty: 0.02456078
p_int: 0.990104436
p_ni: 1.75e-7
p_wrong: 0.009895388
Score: 0.169
Data Source: BioPlex,STRINGDB
DNAJC10
Tbio
Novelty: 0.02258366
p_int: 0.959222616
p_ni: 2.69e-7
p_wrong: 0.040777116
Score: 0.195
Data Source: BioPlex,STRINGDB
NCBP1
Tbio
Novelty: 0.01228885
Score: 0.959
Data Source: STRINGDB
ESRRA
Tchem
Family: NR
Novelty: 0.003235
Score: 0.957
Data Source: Reactome,STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.953
Data Source: STRINGDB
NRF1
Tbio
Family: TF
Novelty: 0.00543248
Score: 0.945
Data Source: Reactome,STRINGDB
NCBP2
Tbio
Novelty: 0.01426734
Score: 0.944
Data Source: STRINGDB
ESRRG
Tchem
Family: NR
Novelty: 0.00544196
Score: 0.933
Data Source: STRINGDB
PPARGC1A
Tbio
Novelty: 0.0003625
Score: 0.929
Data Source: STRINGDB
NR3C1
Tclin
Family: NR
Novelty: 0.00029396
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  87.20

PubMed score by year
PubTator Score  186.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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