Tbio PPARGC1B Peroxisome proliferator-activated receptor gamma coactivator 1-beta

Protein Summary

Description

Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q86YN6
• A2RUM8
• A2RUN0
• B3KVW0
• Q86YN3
• Q86YN4
• Q86YN5
• Q8N1N9
• Q8TDE4
• Q8TDE5
• PGC-1-beta

Gene Name

• PPARGC1B

Ensembl ID

• ENST00000309241
• ENSP00000312649
• ENSG00000155846
• ENST00000360453
• ENSP00000353638
• ENST00000394320
• ENSP00000377855
• ENST00000403750
• ENSP00000384403

Symbol

• PERC
• PGC1
• PGC1B
• PPARGC1
• PERC
• ERRL1
• PGC1B
• PGC-1(beta)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
molecular function	0.9
transcription factor	0.85
transcription factor perturbation	0.8
transcription factor binding site profile	0.79

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Peroxisome Proliferator-activated Receptor Gamma Coactivator 1-beta

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Peroxisome Proliferator-activated Receptor Gamma Coactivator 1-beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.99   (req: < 5)

Gene RIFs: 76   (req: <= 3)

Antibodies: 75   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.99   (req: >= 5)

Gene RIFs: 76   (req: > 3)

Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0