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Tbio
HOMER1
Homer protein homolog 1

Protein Summary
Description
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282260
  • ENSP00000282260
  • ENSG00000152413
  • ENST00000334082
  • ENSP00000334382
  • ENST00000508576
  • ENSP00000426651

Symbol
  • SYN47
  • HOMER
  • SYN47
  • Ves-1
  • HOMER1A
  • HOMER1B
  • HOMER1C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
transcription factor binding site profile
0.83
virus perturbation
0.83
histone modification site profile
0.75
biological process
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 405.17   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 405.17   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (129)
HOMER3
Tbio
Novelty:  0.04408998
p_int:  1
Score:  0.983
Data Source:  BioPlex,Reactome,STRINGDB
HOMER2
Tbio
Novelty:  0.00820449
p_int:  0.999999998
p_ni:  1e-9
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
TRAF5
Tbio
Novelty:  0.01238512
p_int:  0.999998649
p_ni:  0.00000135
p_wrong:  1e-9
Score:  0.715
Data Source:  BioPlex,STRINGDB
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.999996387
p_ni:  0.000003573
p_wrong:  4.1e-8
Score:  0.53
Data Source:  BioPlex,STRINGDB
FBXO28
Tbio
Novelty:  0.10548865
p_int:  0.999995823
p_ni:  0.000004177
Score:  0.179
Data Source:  BioPlex,STRINGDB
DBN1
Tbio
Novelty:  0.00556156
p_int:  0.99999191
p_ni:  0.00000809
Score:  0.789
Data Source:  BioPlex,STRINGDB
MIS18A
Tbio
Novelty:  0.08143008
p_int:  0.999979564
p_ni:  0.000020436
Data Source:  BioPlex
MED4
Tbio
Family:  Enzyme
Novelty:  0.01200585
p_int:  0.999893195
p_ni:  0.000106805
Data Source:  BioPlex
STXBP4
Tbio
Novelty:  0.08831326
p_int:  0.999845072
p_ni:  0.000154928
p_wrong:  1e-9
Data Source:  BioPlex
NUP54
Tbio
Novelty:  0.08155008
p_int:  0.999782179
p_ni:  0.000217821
Data Source:  BioPlex
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
1 – 5 of 7
GRIN1
Tclin
Family:  Ion Channel
KEGG Distance:  4
Common Pathways:  1
GRIN2A
Tclin
Family:  Ion Channel
KEGG Distance:  4
Common Pathways:  1
GRIN3A
Tclin
Family:  Ion Channel
KEGG Distance:  4
Common Pathways:  1
GRIN2C
Tclin
Family:  Ion Channel
KEGG Distance:  4
Common Pathways:  1
GRIN3B
Tclin
Family:  Ion Channel
KEGG Distance:  4
Common Pathways:  1
Pathways (274)
Neurexins and neuroligins (R-HSA-6794361)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
1.7
1
1
1
1.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.7
1
1.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homer scaffold protein 1
VGNC:4038
471504
Macaque
homer scaffolding protein 1
709774
Mouse
MGI:1347345
26556
Rat
RGD:628725
29546
Dog
homer scaffold protein 1
VGNC:41737
488933
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homer scaffold protein 1
Macaque
homer scaffolding protein 1
Mouse
Rat
Dog
homer scaffold protein 1
Publication Statistics
PubMed Score 405.17
PubMed score by year
PubTator Score 98.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title