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Tbio
PDPN
Podoplanin

Protein Summary
Description
Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation (PubMed:14522983, PubMed:15231832, PubMed:17616532, PubMed:18215137, PubMed:17222411). Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN (PubMed:18541721). Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness (PubMed:17046996, PubMed:21376833). Interaction with CD44 promotes directional cell migration in epithelial and tumor cells (PubMed:20962267). In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294489
  • ENSP00000294489
  • ENSG00000162493
  • ENST00000376057
  • ENSP00000365225
  • ENST00000376061
  • ENSP00000365229
  • ENST00000475043
  • ENSP00000426063
  • ENST00000487038
  • ENSP00000427537
  • ENST00000513143
  • ENSP00000425304
  • ENST00000617617
  • ENSP00000479591
  • ENST00000621990
  • ENSP00000478125

Symbol
  • GP36
  • T1A
  • GP36
  • GP40
  • Gp38
  • OTS8
  • T1A2
  • TI1A
  • T1A-2
  • AGGRUS
  • HT1A-1
  • PA2.26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
biological term
0.92
kinase perturbation
0.91
biological process
0.82
gene perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4914.16   (req: < 5)
Gene RIFs: 235   (req: <= 3)
Antibodies: 1133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4914.16   (req: >= 5)
Gene RIFs: 235   (req: > 3)
Antibodies: 1133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0