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Tbio
PDSS2
Decaprenyl-diphosphate synthase subunit 2

Protein Summary
Description
Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10. The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. Defects in this gene are a cause of coenzyme Q10 deficiency.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369031
  • ENSP00000358027
  • ENSG00000164494
  • ENST00000369037
  • ENSP00000358033

Symbol
  • C6orf210
  • DLP1
  • DLP1
  • COQ1B
  • hDLP1
  • COQ10D3
  • C6orf210
  • bA59I9.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor binding site profile
0.84
virus perturbation
0.83
kinase perturbation
0.6
tissue sample
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.65   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.65   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
ACAD9
Tbio
Family:  Enzyme
Novelty:  0.03238308
p_int:  0.999998468
p_ni:  0.000001501
p_wrong:  3.1e-8
Score:  0.426
Data Source:  BioPlex,STRINGDB
SDHA
Tbio
Family:  Enzyme
Novelty:  0.00223171
p_int:  0.999995493
p_ni:  0.000004503
p_wrong:  5e-9
Score:  0.839
Data Source:  BioPlex,STRINGDB
THEM4
Tbio
Family:  Enzyme
Novelty:  0.0191855
p_int:  0.999963465
p_ni:  0.000002259
p_wrong:  0.000034276
Score:  0.188
Data Source:  BioPlex,STRINGDB
FDPS
Tclin
Family:  Enzyme
Novelty:  0.00164195
p_int:  0.999953011
p_ni:  0.000046978
p_wrong:  1e-8
Score:  0.963
Data Source:  BioPlex,STRINGDB
ACAT1
Tchem
Family:  Enzyme
Novelty:  0.00908928
p_int:  0.999850293
p_ni:  0.000147377
p_wrong:  0.00000233
Score:  0.356
Data Source:  BioPlex,STRINGDB
OXLD1
Tdark
Family:  Enzyme
Novelty:  23
p_int:  0.999667247
p_ni:  0.000251477
p_wrong:  0.000081277
Score:  0.199
Data Source:  BioPlex,STRINGDB
MRPS25
Tdark
Novelty:  0.59354314
p_int:  0.998480179
p_ni:  0.001514748
p_wrong:  0.000005073
Data Source:  BioPlex
COQ2
Tbio
Family:  Enzyme
Novelty:  0.00575853
Score:  0.994
Data Source:  STRINGDB
GGPS1
Tchem
Family:  Enzyme
Novelty:  0.00292258
Score:  0.956
Data Source:  STRINGDB
DHDDS
Tbio
Family:  Enzyme
Novelty:  0.02877368
Score:  0.939
Data Source:  STRINGDB
Pathways (7)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of cofactors
Reactome
Metabolism of vitamins and cofactors
Reactome
Ubiquinol biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of cofactors
Metabolism of vitamins and cofactors
Ubiquinol biosynthesis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
2
3
85.5
eosinophil percentage of leukocytes
2
2
2
84.6
lymphocyte count
2
2
2
80.2
lymphocyte percentage of leukocytes
1
1
1
77
monocyte percentage of leukocytes
2
2
2
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
85.5
eosinophil percentage of leukocytes
2
84.6
lymphocyte count
2
80.2
lymphocyte percentage of leukocytes
1
77
monocyte percentage of leukocytes
2
71.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
decaprenyl diphosphate synthase subunit 2
VGNC:14792
462912
Macaque
decaprenyl diphosphate synthase subunit 2
698357
Mouse
MGI:1918615
71365
Rat
RGD:1359372
365592
Dog
decaprenyl diphosphate synthase subunit 2
VGNC:44395
481950
Species
Name
OMA
EggNOG
Inparanoid
Chimp
decaprenyl diphosphate synthase subunit 2
Macaque
decaprenyl diphosphate synthase subunit 2
Mouse
Rat
Dog
decaprenyl diphosphate synthase subunit 2
Publication Statistics
PubMed Score 39.65
PubMed score by year
PubTator Score 36.75
PubTator score by year
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Related Publications
Items per page:
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PMID
Year
Title