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Tbio
PTOV1
Prostate tumor-overexpressed gene 1 protein

Protein Summary
Description
May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391842
  • ENSP00000375717
  • ENSG00000104960
  • ENST00000599732
  • ENSP00000469128
  • ENST00000601675
  • ENSP00000472816

Symbol
  • ACID2
  • ACID2
  • PTOV-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
disease perturbation
0.83
cell type or tissue
0.73
transcription factor binding site profile
0.66
transcription factor
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.74   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.74   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (3)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (58)
1 – 10 of 58
KLHDC2
Tbio
Novelty: 0.01485159
p_int: 0.988074522
p_ni: 0.011925478
Score: 0.549
Data Source: BioPlex,STRINGDB
PEX19
Tbio
Novelty: 0.00605342
p_int: 0.947058929
p_ni: 0.052941071
Score: 0.191
Data Source: BioPlex,STRINGDB
C16orf71
Tdark
Novelty: 0.97826087
p_int: 0.88809778
p_ni: 0.11190222
Score: 0.729
Data Source: BioPlex,STRINGDB
AFAP1L1
Tbio
Novelty: 0.2636613
p_int: 0.882261166
p_ni: 0.117738834
Data Source: BioPlex
FLOT1
Tbio
Novelty: 0.00504569
Score: 0.877
Data Source: STRINGDB
FLOT2
Tbio
Novelty: 0.00727325
Score: 0.808
Data Source: STRINGDB
KMT2A
Tchem
Family: Epigenetic
Novelty: 0.00192554
Score: 0.789
Data Source: STRINGDB
MED6
Tbio
Family: Enzyme
Novelty: 0.05215086
Score: 0.712
Data Source: STRINGDB
SMIM12
Tdark
Novelty: 0.46683938
Score: 0.691
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.67
Data Source: STRINGDB
Publication Statistics
PubMed Score  29.74

PubMed score by year
PubTator Score  174.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer