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Tchem
KMT5C
Histone-lysine N-methyltransferase KMT5C

Protein Summary
Description
Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255613
  • ENSP00000255613
  • ENSG00000133247
  • ENST00000445196
  • ENSP00000397296
  • ENST00000592631
  • ENSP00000467499

Symbol
  • SUV420H2
  • SUV420H2
  • Suv4-20h2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.08   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.08   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
A-196
chemical structure image
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
Protein-Protein Interactions (59)
1 – 10 of 59
KMT5A
Tchem
Family: Epigenetic
Novelty: 0.01205591
Score: 0.809
Data Source: STRINGDB
HIST1H4A
Tbio
Novelty: 0.00536075
Score: 0.798
Data Source: Reactome,STRINGDB
CAMKMT
Tbio
Family: Enzyme
Novelty: 0.00536302
Score: 0.748
Data Source: STRINGDB
SUV39H2
Tbio
Family: Epigenetic
Novelty: 0.03513137
Score: 0.741
Data Source: STRINGDB
SETDB1
Tbio
Family: TF; Epigenetic
Novelty: 0.00522352
Score: 0.73
Data Source: STRINGDB
SUV39H1
Tchem
Family: Epigenetic
Novelty: 0.00504871
Score: 0.72
Data Source: STRINGDB
DOT1L
Tchem
Family: Epigenetic
Novelty: 0.00292525
Score: 0.713
Data Source: STRINGDB
BRSK1
Tchem
Family: Kinase
Novelty: 0.03500246
Score: 0.711
Data Source: STRINGDB
PLOD2
Tbio
Family: Enzyme
Novelty: 0.00389342
Score: 0.65
Data Source: STRINGDB
PLOD3
Tbio
Family: Enzyme
Novelty: 0.02714169
Score: 0.65
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.08

PubMed score by year
PubTator Score  16.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer