Tbio KIF18B Kinesin-like protein KIF18B

Protein Summary

Description

In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.

Uniprot Accession IDs

• Q86Y91
• A6NJI2
• B7ZM49
• B9EGM8
• D5L6I1

Gene Name

• KIF18B

Ensembl ID

• ENST00000590129
• ENSP00000465501
• ENSG00000186185

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
histone modification site profile	0.88
cellular component	0.8
co-expressed gene	0.79
drug perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-like Protein Kif18b

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-like Protein Kif18b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.18   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 23   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.18   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0