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Tbio
STX12
Syntaxin-12

Protein Summary
Description
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373943
  • ENSP00000363054
  • ENSG00000117758

Symbol
  • STX13
  • STX14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor perturbation
0.97
interacting protein
0.86
histone modification site profile
0.81
cellular component
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.2   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.2   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
48.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
48.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin 12
VGNC:1650
456678
Macaque
syntaxin-12 [Source:RefSeq peptide;Acc:NP_001252827]
Mouse
MGI:1931027
100226
Rat
RGD:620977
65033
Horse
syntaxin 12
VGNC:23725
100056769
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin 12
Macaque
syntaxin-12 [Source:RefSeq peptide;Acc:NP_001252827]
Mouse
Rat
Horse
syntaxin 12
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86Y82-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (21)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (190)
1 – 10 of 190
OPTN
Tbio
Novelty: 0.00080427
p_int: 0.999999986
p_ni: 6e-9
p_wrong: 8e-9
Data Source: BioPlex
STXBP5
Tbio
Novelty: 0.01899802
p_int: 0.999999975
p_ni: 2.4e-8
p_wrong: 1e-9
Score: 0.736
Data Source: BioPlex,STRINGDB
NAPG
Tbio
Novelty: 0.02295985
p_int: 0.999999768
p_ni: 2.32e-7
Score: 0.858
Data Source: BioPlex,STRINGDB
VTI1A
Tbio
Novelty: 0.04616617
p_int: 0.999999529
p_ni: 4.62e-7
p_wrong: 9e-9
Score: 0.978
Data Source: BioPlex,STRINGDB
VTI1B
Tbio
Novelty: 0.00955467
p_int: 0.999999479
p_ni: 5.21e-7
Score: 0.939
Data Source: BioPlex,STRINGDB
GOSR1
Tbio
Novelty: 0.03139481
p_int: 0.999999338
p_ni: 6.62e-7
Score: 0.982
Data Source: BioPlex,STRINGDB
ZKSCAN1
Tbio
Family: TF
Novelty: 0.08190662
p_int: 0.999999165
p_ni: 8.35e-7
Score: 0.183
Data Source: BioPlex,STRINGDB
NAPB
Tdark
Novelty: 0.31464404
p_int: 0.999998817
p_ni: 5.81e-7
p_wrong: 6.02e-7
Score: 0.77
Data Source: BioPlex,STRINGDB
STX6
Tbio
Novelty: 0.01494028
p_int: 0.999998537
p_ni: 0.000001463
Score: 0.994
Data Source: BioPlex,STRINGDB
VAMP8
Tbio
Novelty: 0.01083228
p_int: 0.999998397
p_ni: 0.000001477
p_wrong: 1.26e-7
Score: 0.99
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  24.20

PubMed score by year
PubTator Score  4.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer