Tbio LYPD6 Ly6/PLAUR domain-containing protein 6

Protein Summary

Description

Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs (PubMed:27344019). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity). Members of the LY6 protein family (see SLURP1; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010 [PubMed 19653121]).[supplied by OMIM, Apr 2010]

Uniprot Accession IDs

• Q86Y78
• B3KWC0
• Q4G121
• Q53TR3
• Q659B1

Gene Name

• LYPD6

Ensembl ID

• ENST00000334166
• ENSP00000334463
• ENSG00000187123
• ENST00000392854
• ENSP00000376594
• ENST00000409381
• ENSP00000386413
• ENST00000418762
• ENSP00000396855

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
tissue sample	0.75
microRNA	0.71
cell type or tissue	0.56
histone modification site profile	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.59   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 45   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.59   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0