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Tbio
DNAAF5
Dynein assembly factor 5, axonemal

Protein Summary
Description
Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility. The protein encoded by this gene is essential for the preassembly or stability of axonemal dynein arms, and is found only in organisms with motile cilia and flagella. Mutations in this gene are associated with primary ciliary dyskinesia-18, a disorder characterized by abnormalities of motile cilia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297440
  • ENSP00000297440
  • ENSG00000164818

Symbol
  • HEATR2
  • CILD18
  • HEATR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
histone modification site profile
0.77
disease perturbation
0.68
kinase perturbation
0.66
cell line
0.64


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.59   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.59   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
dynein axonemal assembly factor 5
708567
Mouse
MGI:3616079
433956
Rat
RGD:1566028
304332
Dog
dynein axonemal assembly factor 5
VGNC:40010
491598
Horse
dynein axonemal assembly factor 5 [Source:HGNC Symbol;Acc:HGNC:26013]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
dynein axonemal assembly factor 5
Mouse
Rat
Dog
dynein axonemal assembly factor 5
Horse
dynein axonemal assembly factor 5 [Source:HGNC Symbol;Acc:HGNC:26013]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86Y56-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (83)
1 – 10 of 83
B3GAT3
Tbio
Family: Enzyme
Novelty: 0.0289834
p_int: 0.994008787
p_ni: 0.005991213
Score: 0.185
Data Source: BioPlex,STRINGDB
CYB5B
Tbio
Novelty: 0.09395308
p_int: 0.982564481
p_ni: 0.017435519
Data Source: BioPlex
OPRM1
Tclin
Family: GPCR
Novelty: 0.0003701
p_int: 0.951509918
p_ni: 0.048490082
Data Source: BioPlex
NT5E
Tchem
Family: Enzyme
Novelty: 0.00083237
p_int: 0.932176221
p_ni: 0.067823779
Data Source: BioPlex
CHRM4
Tclin
Family: GPCR
Novelty: 0.00759817
p_int: 0.911201257
p_ni: 0.088798743
Data Source: BioPlex
APLNR
Tchem
Family: GPCR
Novelty: 0.00224203
p_int: 0.908888594
p_ni: 0.091111406
Data Source: BioPlex
PTGIR
Tclin
Family: GPCR
Novelty: 0.0091906
p_int: 0.875170036
p_ni: 0.124829964
Data Source: BioPlex
CMTM8
Tbio
Novelty: 0.0953768
p_int: 0.867569943
p_ni: 0.132430057
Data Source: BioPlex
BSG
Tbio
Novelty: 0.0010285
p_int: 0.861214562
p_ni: 0.138785438
Data Source: BioPlex
CMKLR1
Tchem
Family: GPCR
Novelty: 0.00893083
p_int: 0.827739556
p_ni: 0.172260444
Data Source: BioPlex
Publication Statistics
PubMed Score  3.59

PubMed score by year
PubTator Score  1.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer