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Tbio
XYLT1
Xylosyltransferase 1

Protein Summary
Description
Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (PubMed:15461586, PubMed:17189265, PubMed:24581741, PubMed:23982343). Required for normal embryonic and postnatal skeleton development, especially of the long bones (PubMed:24581741, PubMed:23982343). Required for normal maturation of chondrocytes during bone development, and normal onset of ossification (By similarity). This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261381
  • ENSP00000261381
  • ENSG00000103489
  • ENST00000644858
  • ENSP00000495604
  • ENSG00000285395

Symbol
  • XT1
  • XT1
  • XTI
  • XT-I
  • DBQD2
  • XYLTI
  • PXYLT1
  • xylT-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.65
disease
0.63
interacting protein
0.61
tissue sample
0.61
trait
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.14   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.14   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
ADH1C
Tclin
Family:  Enzyme
Novelty:  0.00507607
p_int:  0.993270764
p_wrong:  0.006729236
Score:  0.699
Data Source:  BioPlex,STRINGDB
B4GALT7
Tbio
Family:  Enzyme
Novelty:  0.02175499
Score:  0.982
Data Source:  STRINGDB
DCN
Tbio
Novelty:  0.00073027
Score:  0.941
Data Source:  STRINGDB
HSPG2
Tbio
Family:  Enzyme
Novelty:  0.00159541
Score:  0.935
Data Source:  STRINGDB
NCAN
Tbio
Novelty:  0.00401824
Score:  0.934
Data Source:  STRINGDB
BCAN
Tbio
Novelty:  0.00737982
Score:  0.934
Data Source:  STRINGDB
SDC2
Tbio
Novelty:  0.00597758
Score:  0.933
Data Source:  STRINGDB
VCAN
Tbio
Novelty:  0.00110986
Score:  0.93
Data Source:  STRINGDB
BGN
Tbio
Novelty:  0.00139486
Score:  0.929
Data Source:  STRINGDB
GPC2
Tbio
Novelty:  0.02182363
Score:  0.926
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Glycosaminoglycan metabolism
Reactome
Heparan sulfate/heparin (HS-GAG) metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate/dermatan sulfate metabolism
Glycosaminoglycan metabolism
Heparan sulfate/heparin (HS-GAG) metabolism
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
1
1
1
31.4
1
1
0
3.6
29
risky sexual behaviour measurement
1
1
1
17.8
smoking status measurement
2
1
2
17.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
1
31.4
0
3.6
29
risky sexual behaviour measurement
1
17.8
smoking status measurement
2
17.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
xylosyltransferase 1
VGNC:5958
453955
Macaque
xylosyltransferase 1
718187
Mouse
MGI:2451073
233781
Rat
RGD:620093
64133
Dog
xylosyltransferase 1
VGNC:48475
494008
Species
Name
OMA
EggNOG
Inparanoid
Chimp
xylosyltransferase 1
Macaque
xylosyltransferase 1
Mouse
Rat
Dog
xylosyltransferase 1
Publication Statistics
PubMed Score 187.14
PubMed score by year
PubTator Score 60.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title