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Tbio
CACUL1
CDK2-associated and cullin domain-containing protein 1

Protein Summary
Description
Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369151
  • ENSP00000358147
  • ENSG00000151893
  • ENST00000493518
  • ENSP00000431329

Symbol
  • C10orf46
  • CAC1
  • CAC1
  • C10orf46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
disease perturbation
0.93
transcription factor perturbation
0.91
kinase perturbation
0.81
microRNA
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.73   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.73   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
KBTBD4
Tdark
Novelty:  0.35515885
p_int:  1
Score:  0.557
Data Source:  BioPlex,STRINGDB
UBE2F
Tbio
Novelty:  0.06951245
Score:  0.848
Data Source:  STRINGDB
RBX1
Tbio
Family:  Enzyme
Novelty:  0.00596986
Score:  0.847
Data Source:  STRINGDB
COPS5
Tchem
Novelty:  0.00406225
Score:  0.836
Data Source:  STRINGDB
RNF7
Tbio
Novelty:  0.02532658
Score:  0.812
Data Source:  STRINGDB
NEDD8
Tchem
Novelty:  0.00305343
Score:  0.808
Data Source:  STRINGDB
UBE2M
Tchem
Novelty:  0.02353106
Score:  0.808
Data Source:  STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
Score:  0.807
Data Source:  STRINGDB
TM9SF1
Tdark
Novelty:  0.2874029
Score:  0.751
Data Source:  STRINGDB
CAND1
Tbio
Novelty:  0.0196525
Score:  0.685
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
0
5.5
1.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
0
5.5
1.6
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDK2 associated cullin domain 1
VGNC:7222
450771
Macaque
CDK2 associated cullin domain 1
702200
Mouse
MGI:1926082
78832
Rat
RGD:1308127
365493
Dog
CDK2 associated cullin domain 1
VGNC:38654
477836
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDK2 associated cullin domain 1
Macaque
CDK2 associated cullin domain 1
Mouse
Rat
Dog
CDK2 associated cullin domain 1
Publication Statistics
PubMed Score 9.73
PubMed score by year
PubTator Score 138.85
PubTator score by year
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Related Publications
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PMID
Year
Title