Tchem ADGRG3 Adhesion G protein-coupled receptor G3

Protein Summary

Description

Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed:22575658).

Uniprot Accession IDs

• Q86Y34
• Q6ZMF4
• Q86SL9
• Q8IZF1

Gene Name

• ADGRG3

Ensembl ID

• ENST00000333493
• ENSP00000332900
• ENSG00000182885

Symbol

• GPR97
• PGR26
• PB99
• GPR97
• PGR26

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.71
tissue sample	0.63
protein domain	0.58
cell line	0.55
disease perturbation	0.49

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Adhesion G Protein-coupled Receptor G3

Protein / Defense/immunity Protein / Antibacterial Response Protein / Adhesion G Protein-coupled Receptor G3

Protein / ... / Protease / Adhesion G Protein-coupled Receptor G3

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / Adhesion G Protein-coupled Receptor G3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.19   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.19   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1