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Tchem
ADGRG3
Adhesion G protein-coupled receptor G3

Protein Summary
Description
Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed:22575658).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333493
  • ENSP00000332900
  • ENSG00000182885

Symbol
  • GPR97
  • PGR26
  • PB99
  • GPR97
  • PGR26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.71
tissue sample
0.63
protein domain
0.58
cell line
0.55
disease perturbation
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.48   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.48   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (101)
1 – 10 of 101
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
Score:  0.915
Data Source:  STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
Score:  0.914
Data Source:  STRINGDB
GPR84
Tchem
Family:  GPCR
Novelty:  0.02360587
Score:  0.913
Data Source:  STRINGDB
MMP25
Tchem
Family:  Enzyme
Novelty:  0.01860638
Score:  0.907
Data Source:  STRINGDB
CEACAM3
Tbio
Novelty:  0.02597577
Score:  0.906
Data Source:  STRINGDB
OLR1
Tbio
Novelty:  0.00123609
Score:  0.903
Data Source:  STRINGDB
CYBB
Tchem
Family:  IC
Novelty:  0.00054866
Score:  0.902
Data Source:  STRINGDB
RAB37
Tbio
Family:  Enzyme
Novelty:  0.07133253
Score:  0.902
Data Source:  STRINGDB
P2RX1
Tchem
Family:  IC
Novelty:  0.00286826
Score:  0.902
Data Source:  STRINGDB
MCEMP1
Tdark
Novelty:  0.14180782
Score:  0.902
Data Source:  STRINGDB
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
61.8
high density lipoprotein cholesterol measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
61.8
high density lipoprotein cholesterol measurement
1
14.2
Find similar targets by:
IDG Resources
Mouse
image for
Details:
  • Allele:  Insertion
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor G3
VGNC:13654
454122
Macaque
adhesion G protein-coupled receptor G3
705580
Mouse
MGI:1859670
54672
Rat
RGD:1305674
291854
Dog
adhesion G protein-coupled receptor G3
VGNC:37645
611191
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor G3
Macaque
adhesion G protein-coupled receptor G3
Mouse
Rat
Dog
adhesion G protein-coupled receptor G3
Publication Statistics
PubMed Score 10.48
PubMed score by year
PubTator Score 3.94
PubTator score by year
Patents
Patents by year