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Tchem
ADGRG3
Adhesion G protein-coupled receptor G3

Protein Summary
Description
Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed:22575658).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333493
  • ENSP00000332900
  • ENSG00000182885

Symbol
  • GPR97
  • PGR26
  • PB99
  • GPR97
  • PGR26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.71
tissue sample
0.63
protein domain
0.58
cell line
0.55
disease perturbation
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.2   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.2   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (101)
1 – 10 of 101
FPR2
Tchem
Family: GPCR
Novelty: 0.00286277
Score: 0.915
Data Source: STRINGDB
C3AR1
Tchem
Family: GPCR
Novelty: 0.00700844
Score: 0.914
Data Source: STRINGDB
GPR84
Tchem
Family: GPCR
Novelty: 0.03403502
Score: 0.913
Data Source: STRINGDB
MMP25
Tchem
Family: Enzyme
Novelty: 0.02629058
Score: 0.907
Data Source: STRINGDB
CEACAM3
Tbio
Novelty: 0.03544819
Score: 0.906
Data Source: STRINGDB
OLR1
Tbio
Novelty: 0.00140219
Score: 0.903
Data Source: STRINGDB
CYBB
Tchem
Family: IC
Novelty: 0.00068038
Score: 0.902
Data Source: STRINGDB
RAB37
Tbio
Family: Enzyme
Novelty: 0.09047828
Score: 0.902
Data Source: STRINGDB
MCEMP1
Tdark
Novelty: 0.2
Score: 0.902
Data Source: STRINGDB
P2RX1
Tchem
Family: IC
Novelty: 0.00376724
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.20

PubMed score by year
PubTator Score  3.94

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer