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Tbio
COL23A1
Collagen alpha-1(XXIII) chain

Protein Summary
Description
COL23A1 is a member of the transmembrane collagens, a subfamily of the nonfibrillar collagens that contain a single pass hydrophobic transmembrane domain (Banyard et al., 2003 [PubMed 12644459]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000390654
  • ENSP00000375069
  • ENSG00000050767
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.75
cellular component
0.67
transcription factor binding site profile
0.67
phenotype
0.64
histone modification site profile
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.46   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.46   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
83.9
reticulocyte measurement
2
1
2
73.7
reticulocyte count
1
1
1
70
platelet count
2
2
2
58.2
balding measurement
1
2
2
55.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
83.9
reticulocyte measurement
2
73.7
reticulocyte count
1
70
platelet count
2
58.2
balding measurement
2
55.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type XXIII alpha 1 chain
VGNC:11890
462321
Mouse
MGI:2653243
237759
Rat
RGD:727898
353303
Rat
RGD:9310824
103693323
Dog
collagen type XXIII alpha 1 chain
VGNC:51705
607556
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type XXIII alpha 1 chain
Mouse
Rat
Rat
Dog
collagen type XXIII alpha 1 chain
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86Y22-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen degradation
Reactome
Collagen formation
Reactome
Degradation of the extracellular matrix
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen degradation
Collagen formation
Degradation of the extracellular matrix
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (76)
1 – 10 of 76
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
Score:  0.969
Data Source:  STRINGDB
COL26A1
Tbio
Novelty:  0.07322658
Score:  0.95
Data Source:  STRINGDB
P3H1
Tbio
Family:  Enzyme
Novelty:  0.02067711
Score:  0.921
Data Source:  STRINGDB
COL16A1
Tbio
Novelty:  0.11147945
Score:  0.921
Data Source:  STRINGDB
COL9A3
Tbio
Novelty:  0.02556037
Score:  0.921
Data Source:  STRINGDB
COL8A1
Tbio
Novelty:  0.02203574
Score:  0.921
Data Source:  STRINGDB
COL13A1
Tbio
Novelty:  0.040988
Score:  0.92
Data Source:  STRINGDB
COL4A2
Tbio
Novelty:  0.00782053
Score:  0.92
Data Source:  STRINGDB
COL9A1
Tbio
Novelty:  0.0160066
Score:  0.92
Data Source:  STRINGDB
COL5A3
Tbio
Novelty:  0.06365591
Score:  0.92
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.46

PubMed score by year
PubTator Score  2.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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