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Tbio
VRK2
Serine/threonine-protein kinase VRK2

Protein Summary
Description
Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevan ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340157
  • ENSP00000342381
  • ENSG00000028116
  • ENST00000412104
  • ENSP00000404156
  • ENST00000417641
  • ENSP00000402375
  • ENST00000435505
  • ENSP00000408002
  • ENST00000440705
  • ENSP00000398323
  • ENST00000648897
  • ENSP00000497378
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
molecular function
0.91
histone modification site profile
0.87
transcription factor perturbation
0.84
cell line
0.69


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.4   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.4   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
6
0
1.1
98.6
mathematical ability
4
3
5
95.4
unipolar depression
3
4
2
5.8
91.9
neuroticism measurement
4
6
2
6.1
90.7
wellbeing measurement
4
3
4
90.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
98.6
mathematical ability
5
95.4
unipolar depression
2
5.8
91.9
neuroticism measurement
2
6.1
90.7
wellbeing measurement
4
90.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vaccinia related kinase 2
VGNC:413
459250
Macaque
vaccinia related kinase 2
719132
Mouse
MGI:1917172
69922
Rat
RGD:1311585
360991
Dog
vaccinia related kinase 2
VGNC:48303
474605
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vaccinia related kinase 2
Macaque
vaccinia related kinase 2
Mouse
Rat
Dog
vaccinia related kinase 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86Y07-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Initiation of Nuclear Envelope Reformation
Reactome
M Phase
Reactome
Mitotic Anaphase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Initiation of Nuclear Envelope Reformation
M Phase
Mitotic Anaphase
Protein-Protein Interactions (58)
1 – 10 of 58
FAF2
Tbio
Novelty: 0.03048598
p_int: 0.972838775
p_ni: 0.027161225
Score: 0.35
Data Source: BioPlex,STRINGDB
TMPRSS3
Tbio
Family: Enzyme
Novelty: 0.0268524
p_int: 0.952347955
p_ni: 0.047652045
Score: 0.179
Data Source: BioPlex,STRINGDB
ZNRF4
Tbio
Novelty: 0.16505328
p_int: 0.935028156
p_ni: 0.064971844
Data Source: BioPlex
SPINT2
Tbio
Family: Enzyme
Novelty: 0.0046602
p_int: 0.91784432
p_ni: 0.08215568
Data Source: BioPlex
SRPRB
Tbio
Novelty: 0.04735362
p_int: 0.88595069
p_ni: 0.11404931
Score: 0.18
Data Source: BioPlex,STRINGDB
FAM187B
Tdark
Novelty: 0.59092623
p_int: 0.880563869
p_ni: 0.119436131
Score: 0.204
Data Source: BioPlex,STRINGDB
BDKRB1
Tchem
Family: GPCR
Novelty: 0.00625504
Score: 0.8
Data Source: STRINGDB
BANF1
Tbio
Novelty: 0.00092814
Score: 0.792
Data Source: STRINGDB
KSR1
Tbio
Family: Kinase
Novelty: 0.00691155
Score: 0.771
Data Source: STRINGDB
F10
Tclin
Family: Enzyme
Novelty: 0.00063008
Score: 0.756
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.40

PubMed score by year
PubTator Score  23.05

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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