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Tbio
VRK2
Serine/threonine-protein kinase VRK2

Protein Summary
Description
Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevan ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340157
  • ENSP00000342381
  • ENSG00000028116
  • ENST00000412104
  • ENSP00000404156
  • ENST00000417641
  • ENSP00000402375
  • ENST00000435505
  • ENSP00000408002
  • ENST00000440705
  • ENSP00000398323
  • ENST00000648897
  • ENSP00000497378
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
molecular function
0.91
histone modification site profile
0.87
transcription factor perturbation
0.84
cell line
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.27   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.27   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Initiation of Nuclear Envelope Reformation
Reactome
M Phase
Reactome
Mitotic Anaphase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Initiation of Nuclear Envelope Reformation
M Phase
Mitotic Anaphase
Protein-Protein Interactions (58)
1 – 10 of 58
FAF2
Tbio
Novelty: 0.03242029
p_int: 0.972838775
p_ni: 0.027161225
Score: 0.35
Data Source: BioPlex,STRINGDB
TMPRSS3
Tbio
Family: Enzyme
Novelty: 0.03356847
p_int: 0.952347955
p_ni: 0.047652045
Score: 0.179
Data Source: BioPlex,STRINGDB
ZNRF4
Tbio
Novelty: 0.18181818
p_int: 0.935028156
p_ni: 0.064971844
Data Source: BioPlex
SPINT2
Tbio
Family: Enzyme
Novelty: 0.00575409
p_int: 0.91784432
p_ni: 0.08215568
Data Source: BioPlex
SRPRB
Tbio
Novelty: 0.03850629
p_int: 0.88595069
p_ni: 0.11404931
Score: 0.18
Data Source: BioPlex,STRINGDB
FAM187B
Tdark
Novelty: 0.90909091
p_int: 0.880563869
p_ni: 0.119436131
Score: 0.204
Data Source: BioPlex,STRINGDB
BDKRB1
Tchem
Family: GPCR
Novelty: 0.00970298
Score: 0.8
Data Source: STRINGDB
BANF1
Tbio
Novelty: 0.0011638
Score: 0.792
Data Source: STRINGDB
KSR1
Tbio
Family: Kinase
Novelty: 0.0074785
Score: 0.771
Data Source: STRINGDB
F10
Tclin
Family: Enzyme
Novelty: 0.0007229
Score: 0.756
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.27

PubMed score by year
PubTator Score  23.05

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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