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Tbio
NME9
Thioredoxin domain-containing protein 6

Protein Summary
Description
May be a regulator of microtubule physiology.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317876
  • ENSP00000321929
  • ENSG00000181322
  • ENST00000333911
  • ENSP00000335444
  • ENST00000383180
  • ENSP00000372667
  • ENST00000484930
  • ENSP00000419882

Symbol
  • TXL2
  • TXNDC6
  • TXL2
  • TXL-2
  • TXNDC6
  • NM23-H9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
biological process
0.72
histone modification site profile
0.65
microRNA
0.61
cell type or tissue
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.23   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.23   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
6
4
1.1
91.1
waist circumference
1
3
3
84.6
BMI-adjusted waist-hip ratio
2
4
4
83.2
waist-hip ratio
1
3
3
81.6
testosterone measurement
3
2
3
75.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
91.1
waist circumference
3
84.6
BMI-adjusted waist-hip ratio
4
83.2
waist-hip ratio
3
81.6
testosterone measurement
3
75.7
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NME/NM23 family member 9
VGNC:53377
745445
Rat
Dog
NME/NM23 family member 9
VGNC:43860
485685
Cow
NME/NM23 family member 9
VGNC:32131
513348
Opossum
NME/NM23 family member 9
100618853
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NME/NM23 family member 9
Rat
Dog
NME/NM23 family member 9
Cow
NME/NM23 family member 9
Opossum
NME/NM23 family member 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86XW9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (36)
1 – 10 of 36
TXNRD1
Tclin
Family:  Enzyme
Novelty:  0.00299018
Score:  0.743
Data Source:  STRINGDB
TXNL1
Tbio
Novelty:  0.01151931
Score:  0.712
Data Source:  STRINGDB
TXNDC2
Tbio
Novelty:  0.10794522
Score:  0.698
Data Source:  STRINGDB
TXNDC8
Tbio
Novelty:  0.15772943
Score:  0.669
Data Source:  STRINGDB
GSR
Tclin
Family:  Enzyme
Novelty:  0.00040107
Score:  0.634
Data Source:  STRINGDB
GLRX3
Tbio
Novelty:  0.0096265
Score:  0.606
Data Source:  STRINGDB
PRDX5
Tbio
Novelty:  0.00369421
Score:  0.577
Data Source:  STRINGDB
RALA
Tbio
Family:  Enzyme
Novelty:  0.00257914
Score:  0.535
Data Source:  STRINGDB
PRDX6
Tbio
Novelty:  0.00180564
Score:  0.518
Data Source:  STRINGDB
SRXN1
Tbio
Novelty:  0.00780861
Score:  0.517
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.23

PubMed score by year
PubTator Score  5.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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