Tdark TMEM219 Insulin-like growth factor-binding protein 3 receptor

Protein Summary

Description

Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.

Uniprot Accession IDs

• Q86XT9
• D5FK14
• Q8WVV8
• IGFBP-3R

Gene Name

• TMEM219

Ensembl ID

• ENST00000279396
• ENSP00000279396
• ENSG00000149932
• ENST00000414689
• ENSP00000388485
• ENST00000561899
• ENSP00000456960
• ENST00000566848
• ENSP00000457492

Symbol

• IGFBP-3R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
transcription factor perturbation	0.84
transcription factor	0.67
transcription factor binding site profile	0.62
tissue sample	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.74   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 9   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.74   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0