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Tdark
TMEM219
Insulin-like growth factor-binding protein 3 receptor

Protein Summary
Description
Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279396
  • ENSP00000279396
  • ENSG00000149932
  • ENST00000414689
  • ENSP00000388485
  • ENST00000561899
  • ENSP00000456960
  • ENST00000566848
  • ENSP00000457492

Symbol
  • IGFBP-3R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor perturbation
0.84
transcription factor
0.67
transcription factor binding site profile
0.62
tissue sample
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.95   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 9   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.95   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
2
2
96.1
visceral adipose tissue measurement
1
1
1
93.9
2
1
2
85.8
body mass index
2
1
2
78.4
2
2
0
1.1
61.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
96.1
visceral adipose tissue measurement
1
93.9
2
85.8
body mass index
2
78.4
0
1.1
61.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 219
VGNC:5941
454031
Macaque
transmembrane protein 219
707670
Mouse
MGI:1915992
68742
Dog
transmembrane protein 219
VGNC:47535
479785
Horse
transmembrane protein 219
VGNC:24260
100064015
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 219
Macaque
transmembrane protein 219
Mouse
Dog
transmembrane protein 219
Horse
transmembrane protein 219
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86XT9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of Cell Death Genes
Reactome
TP53 Regulates Transcription of Death Receptors and Ligands
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of Cell Death Genes
TP53 Regulates Transcription of Death Receptors and Ligands
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (50)
1 – 10 of 50
NRN1
Tbio
Novelty: 0.01198116
p_int: 0.999130524
p_ni: 0.000869475
p_wrong: 1e-9
Data Source: BioPlex
NKAIN1
Tdark
Family: Enzyme
Novelty: 0.52190272
p_int: 0.99760383
p_ni: 0.002328597
p_wrong: 0.000067573
Data Source: BioPlex
UPK1A
Tbio
Novelty: 0.01748122
p_int: 0.996331123
p_ni: 0.003596389
p_wrong: 0.000072488
Data Source: BioPlex
HLA-DQA1
Tbio
Novelty: 0.00077488
p_int: 0.996264602
p_ni: 0.003660364
p_wrong: 0.000075034
Score: 0.163
Data Source: BioPlex,STRINGDB
ITM2B
Tbio
Novelty: 0.00977027
p_int: 0.996182301
p_ni: 0.003817699
Score: 0.163
Data Source: BioPlex,STRINGDB
MCOLN3
Tchem
Family: IC
Novelty: 0.03209262
p_int: 0.996142337
p_ni: 0.003676158
p_wrong: 0.000181505
Data Source: BioPlex
HFE
Tbio
Novelty: 0.00042077
p_int: 0.992394389
p_ni: 0.007579312
p_wrong: 0.000026299
Data Source: BioPlex
CHRNA3
Tclin
Family: IC
Novelty: 0.00659767
p_int: 0.992382475
p_ni: 0.007553667
p_wrong: 0.000063857
Data Source: BioPlex
BTNL8
Tdark
Novelty: 0.40339869
p_int: 0.948705702
p_ni: 0.015569429
p_wrong: 0.035724868
Score: 0.175
Data Source: BioPlex,STRINGDB
TCTN2
Tbio
Novelty: 0.11617528
p_int: 0.926360612
p_ni: 0.018129331
p_wrong: 0.055510057
Data Source: BioPlex
Publication Statistics
PubMed Score  1.95

PubMed score by year
PubTator Score  2.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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