Tbio TRIM50 E3 ubiquitin-protein ligase TRIM50

Protein Summary

Description

E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction.

Uniprot Accession IDs

• Q86XT4
• Q86XT3

Gene Name

• TRIM50

Ensembl ID

• ENST00000333149
• ENSP00000327994
• ENSG00000146755
• ENST00000453152
• ENSP00000413875

Symbol

• TRIM50A
• TRIM50A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
cell line	0.65
tissue sample	0.64
tissue	0.42
cell type or tissue	0.38

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.13   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 122   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.13   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0