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Tbio
TRIM50
E3 ubiquitin-protein ligase TRIM50

Protein Summary
Description
E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333149
  • ENSP00000327994
  • ENSG00000146755
  • ENST00000453152
  • ENSP00000413875

Symbol
  • TRIM50A
  • TRIM50A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
cell line
0.65
tissue sample
0.64
tissue
0.42
cell type or tissue
0.38


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.24   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.24   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
2
2
60.8
body height
1
1
1
46.1
protein C measurement
1
1
1
3.5
high density lipoprotein cholesterol measurement
1
1
1
3.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
60.8
body height
1
46.1
protein C measurement
1
3.5
high density lipoprotein cholesterol measurement
1
3.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 50
VGNC:14101
472403
Macaque
tripartite motif containing 50
716264
Mouse
MGI:2664992
215061
Rat
RGD:631346
288596
Dog
tripartite motif containing 50
489811
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 50
Macaque
tripartite motif containing 50
Mouse
Rat
Dog
tripartite motif containing 50
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86XT4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (287)
1 – 10 of 287
UBE2E1
Tbio
Novelty:  0.04048768
Score:  0.956
Data Source:  STRINGDB
UBE2E3
Tbio
Novelty:  0.03477232
Score:  0.946
Data Source:  STRINGDB
TRIM9
Tbio
Family:  Enzyme
Novelty:  0.06250762
Score:  0.939
Data Source:  STRINGDB
UBE2L6
Tbio
Novelty:  0.03471633
Score:  0.939
Data Source:  STRINGDB
RNF220
Tbio
Family:  Enzyme
Novelty:  0.14024436
Score:  0.936
Data Source:  STRINGDB
TRIM37
Tbio
Family:  Enzyme
Novelty:  0.02515451
Score:  0.934
Data Source:  STRINGDB
RNF25
Tbio
Family:  Enzyme
Novelty:  0.08945219
Score:  0.933
Data Source:  STRINGDB
SPSB4
Tdark
Novelty:  0.07251424
Score:  0.93
Data Source:  STRINGDB
UBE2S
Tbio
Novelty:  0.00363304
Score:  0.929
Data Source:  STRINGDB
TRIM71
Tbio
Family:  Enzyme
Novelty:  0.01164618
Score:  0.925
Data Source:  STRINGDB
Publication Statistics
PubMed Score  6.24

PubMed score by year
PubTator Score  2.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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