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Tbio
CEP57
Centrosomal protein of 57 kDa

Protein Summary
Description
Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1. This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for main ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325486
  • ENSP00000317487
  • ENSG00000166037
  • ENST00000325542
  • ENSP00000317902
  • ENST00000538658
  • ENSP00000445706
  • ENST00000541150
  • ENSP00000443436

Symbol
  • KIAA0092
  • TSP57
  • MVA2
  • PIG8
  • TSP57
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor binding site profile
0.89
transcription factor
0.81
cellular component
0.74
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.92   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.92   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Protein-Protein Interactions (146)
1 – 10 of 146
TNFRSF8
Tclin
Novelty: 0.00035482
p_int: 0.999995282
p_ni: 0.000004645
p_wrong: 7.3e-8
Score: 0.209
Data Source: BioPlex,STRINGDB
DISC1
Tbio
Novelty: 0.00165188
p_int: 0.999870388
p_ni: 0.000128923
p_wrong: 6.89e-7
Data Source: BioPlex
CDH5
Tbio
Novelty: 0.00096405
p_int: 0.964345221
p_ni: 0.000028098
p_wrong: 0.03562668
Score: 0.169
Data Source: BioPlex,STRINGDB
CEP63
Tbio
Novelty: 0.14021741
Score: 0.971
Data Source: STRINGDB
CEP152
Tbio
Novelty: 0.03983445
Score: 0.969
Data Source: STRINGDB
NEDD1
Tbio
Novelty: 0.03704684
Score: 0.954
Data Source: STRINGDB
PLK4
Tchem
Family: Kinase
Novelty: 0.00451442
Score: 0.951
Data Source: STRINGDB
CEP78
Tbio
Novelty: 0.19047619
Score: 0.95
Data Source: STRINGDB
CEP70
Tbio
Novelty: 0.00281605
Score: 0.948
Data Source: STRINGDB
CEP164
Tbio
Novelty: 0.07209475
Score: 0.937
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.92

PubMed score by year
PubTator Score  17.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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