Tbio TICAM2 TIR domain-containing adapter molecule 2

Protein Summary

Description

Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes. This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• Q86XR7
• B3Y698
• Q6JUT2
• TICAM-2

Gene Name

• TICAM2

Ensembl ID

• ENST00000427199
• ENSP00000415139
• ENSG00000243414

Symbol

• TIRAP3
• TIRP
• TRAM
• TIRP
• TRAM
• TICAM2
• TIRAP3
• MyD88-4
• TICAM-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.94
histone modification site profile	0.75
tissue	0.68
tissue sample	0.62
microRNA	0.61

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Tir Domain-containing Adapter Molecule 2

Protein / Membrane Traffic Protein / Vesicle Coat Protein / Tir Domain-containing Adapter Molecule 2

DTO Classes

Protein / Transporter / Vesicle Coat Protein / Tir Domain-containing Adapter Molecule 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.72   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 313   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.72   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0