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Tchem
CATSPER3
Cation channel sperm-associated protein 3

Protein Summary
Description
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282611
  • ENSP00000282611
  • ENSG00000152705

Symbol
  • CACRC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.84
molecular function
0.81
cellular component
0.7
gene perturbation
0.65
virus perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.18   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.18   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
4
4
94.2
heel bone mineral density
2
2
2
83.7
1
1
0
1.2
7.9
anthropometric measurement
1
1
0
1.1
3.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
94.2
heel bone mineral density
2
83.7
0
1.2
7.9
anthropometric measurement
0
1.1
3.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cation channel sperm associated 3
VGNC:11868
471637
Macaque
cation channel sperm associated 3
713905
Mouse
MGI:1924106
76856
Rat
RGD:1305700
290989
Dog
cation channel sperm associated 3
VGNC:38746
481512
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cation channel sperm associated 3
Macaque
cation channel sperm associated 3
Mouse
Rat
Dog
cation channel sperm associated 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86XQ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Fertilization (R-HSA-1187000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fertilization
Reactome
Reproduction
Reactome
Sperm Motility And Taxes
Name
Explore in Pharos
Explore in Source
Fertilization
Reproduction
Sperm Motility And Taxes
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (56)
1 – 10 of 56
CATSPERD
Tdark
Novelty: 0.85066163
Score: 0.967
Data Source: Reactome,STRINGDB
CATSPERG
Tdark
Novelty: 0.73161601
Score: 0.965
Data Source: Reactome,STRINGDB
CATSPERB
Tdark
Novelty: 0.69373919
Score: 0.96
Data Source: Reactome,STRINGDB
CATSPER4
Tchem
Family: IC
Novelty: 0.4554917
Score: 0.941
Data Source: Reactome,STRINGDB
CATSPER1
Tchem
Family: IC
Novelty: 0.01971564
Score: 0.937
Data Source: Reactome,STRINGDB
CATSPER2
Tchem
Family: IC
Novelty: 0.03701031
Score: 0.936
Data Source: Reactome,STRINGDB
PCBD2
Tbio
Family: Enzyme
Novelty: 0.11676823
Score: 0.902
Data Source: STRINGDB
CACNA2D4
Tbio
Family: IC
Novelty: 0.02238343
Score: 0.82
Data Source: STRINGDB
CACNB2
Tbio
Family: IC
Novelty: 0.01745218
Score: 0.805
Data Source: STRINGDB
CACNB3
Tbio
Family: IC
Novelty: 0.04007679
Score: 0.805
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.18

PubMed score by year
PubTator Score  7.62

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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