Tchem CATSPER3 Cation channel sperm-associated protein 3

Protein Summary

Description

Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.

Uniprot Accession IDs

• Q86XQ3
• Q86XS6
• CatSper3

Gene Name

• CATSPER3

Ensembl ID

• ENST00000282611
• ENSP00000282611
• ENSG00000152705

Symbol

• CACRC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.84
molecular function	0.81
cellular component	0.7
gene perturbation	0.65
virus perturbation	0.64

Protein Classes

DTO Classes

Protein / Ion Channel / Cation Channel Sperm-associated Family / Cation Channel Sperm-associated Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.01   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 41   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.01   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3