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Tbio
DGKH
Diacylglycerol kinase eta

Protein Summary
Description
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization. This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family. Members of this family are involved in regulating intracellular concentrations of diacylglycerol and phosphatidic acid. Variation in this gene has been associated with bipolar disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261491
  • ENSP00000261491
  • ENSG00000102780
  • ENST00000337343
  • ENSP00000337572
  • ENST00000379274
  • ENSP00000368576
  • ENST00000536612
  • ENSP00000445114
  • ENST00000628433
  • ENSP00000485809

Symbol
  • DGKeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
trait
0.99
molecular function
0.93
metabolite
0.83
cellular component
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.97   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.97   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
90.8
neutrophil count
2
2
2
75.6
urolithiasis
1
1
0
1.1
74.5
glomerular filtration rate
3
3
2
6.9
68.8
creatinine measurement
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
90.8
neutrophil count
2
75.6
urolithiasis
0
1.1
74.5
glomerular filtration rate
2
6.9
68.8
creatinine measurement
1
50.6
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
diacylglycerol kinase eta
VGNC:14531
452564
Macaque
diacylglycerol kinase eta
699337
Mouse
MGI:2444188
380921
Rat
RGD:1561955
361076
Dog
diacylglycerol kinase eta
VGNC:39920
476932
Species
Name
OMA
EggNOG
Inparanoid
Chimp
diacylglycerol kinase eta
Macaque
diacylglycerol kinase eta
Mouse
Rat
Dog
diacylglycerol kinase eta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86XP1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Effects of PIP2 hydrolysis (R-HSA-114508)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Effects of PIP2 hydrolysis
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Effects of PIP2 hydrolysis
G alpha (q) signalling events
GPCR downstream signalling
Hemostasis
Platelet activation, signaling and aggregation
Gene Ontology Terms (15)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (88)
1 – 10 of 88
DGKG
Tbio
Family:  Enzyme
Novelty:  0.03666646
p_int:  0.999999973
p_ni:  2.6e-8
Score:  0.204
Data Source:  BioPlex,STRINGDB
LINC01587
Tdark
Novelty:  0.48128342
p_int:  0.999973008
p_ni:  0.000026969
p_wrong:  2.3e-8
Score:  0.248
Data Source:  BioPlex,STRINGDB
DEUP1
Tbio
Novelty:  0.13274391
p_int:  0.998446417
p_ni:  0.000012693
p_wrong:  0.00154089
Score:  0.243
Data Source:  BioPlex,STRINGDB
MAGIX
Tdark
Novelty:  0.38577176
p_int:  0.915215045
p_ni:  0.000106876
p_wrong:  0.084678079
Score:  0.239
Data Source:  BioPlex,STRINGDB
MOGAT1
Tbio
Family:  Enzyme
Novelty:  0.0503068
Score:  0.783
Data Source:  STRINGDB
CHPT1
Tbio
Family:  Enzyme
Novelty:  0.02875977
Score:  0.782
Data Source:  STRINGDB
CDS2
Tbio
Family:  Enzyme
Novelty:  0.13210626
Score:  0.782
Data Source:  STRINGDB
PLCD4
Tbio
Family:  Enzyme
Novelty:  0.07014141
Score:  0.756
Data Source:  STRINGDB
AGPAT5
Tbio
Family:  Enzyme
Novelty:  0.23785857
Score:  0.754
Data Source:  STRINGDB
PLCZ1
Tbio
Family:  Enzyme
Novelty:  0.0059826
Score:  0.752
Data Source:  STRINGDB
Publication Statistics
PubMed Score  67.97

PubMed score by year
PubTator Score  31.39

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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