Tbio PLA2G4D Cytosolic phospholipase A2 delta

Protein Summary

Description

Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:14709560). May have a substrate specificity for linoleic acid at the sn-2 position (PubMed:14709560). The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids (Chiba et al., 2004 [PubMed 14709560]).[supplied by OMIM, Jun 2009]

Uniprot Accession IDs

• Q86XP0
• Q8N176
• cPLA2-delta

Gene Name

• PLA2G4D

Ensembl ID

• ENST00000290472
• ENSP00000290472
• ENSG00000159337

Symbol

• cPLA2delta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	0.78
microRNA	0.73
cell type or tissue	0.62
biological process	0.48
cellular component	0.42

Protein Classes

PANTHER Classes

Protein / Hydrolase / Lipase / Phospholipase / Cytosolic Phospholipase A2 Delta

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase / Cytosolic Phospholipase A2 Delta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.69   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 65   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.69   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0