You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
CATSPERD
Cation channel sperm-associated protein subunit delta

Protein Summary
Description
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381624
  • ENSP00000371037
  • ENSG00000174898

Symbol
  • TMEM146
  • TMEM146
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.84
transcription factor binding site profile
0.67
transcription factor
0.49
histone modification site profile
0.48
cell line
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.13   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.13   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (52)
1 – 10 of 52
HLCS
Tchem
Family:  Enzyme
Novelty:  0.01597449
p_int:  0.999990427
p_ni:  0.000009573
Score:  0.685
Data Source:  BioPlex,STRINGDB
CATSPERG
Tdark
Novelty:  0.73161601
Score:  0.984
Data Source:  STRINGDB
CATSPERB
Tdark
Novelty:  0.69373919
Score:  0.983
Data Source:  STRINGDB
CATSPER1
Tchem
Family:  IC
Novelty:  0.01971564
Score:  0.972
Data Source:  Reactome,STRINGDB
CATSPER3
Tchem
Family:  IC
Novelty:  0.09919608
Score:  0.967
Data Source:  Reactome,STRINGDB
CATSPER4
Tchem
Family:  IC
Novelty:  0.4554917
Score:  0.965
Data Source:  Reactome,STRINGDB
CATSPER2
Tchem
Family:  IC
Novelty:  0.03701031
Score:  0.96
Data Source:  Reactome,STRINGDB
CATSPERZ
Tdark
Novelty:  0.61619097
Score:  0.863
Data Source:  STRINGDB
CACNA1H
Tclin
Family:  IC
Novelty:  0.00342394
Score:  0.827
Data Source:  STRINGDB
CATSPERE
Tdark
Novelty:  0.95910237
Score:  0.819
Data Source:  STRINGDB
Pathways (3)
Fertilization (R-HSA-1187000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fertilization
Reactome
Reproduction
Reactome
Sperm Motility And Taxes
Name
Explore in Pharos
Explore in Source
Fertilization
Reproduction
Sperm Motility And Taxes
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer biomarker measurement
1
3
4
97
cancer antigen 19.9 measurement
1
2
2
91
vitamin B12 measurement
2
3
2
49.8
88.8
N-glycan measurement
2
1
18
79.4
aspartate aminotransferase measurement
1
1
0
10.1
76
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer biomarker measurement
4
97
cancer antigen 19.9 measurement
2
91
vitamin B12 measurement
2
49.8
88.8
N-glycan measurement
18
79.4
aspartate aminotransferase measurement
0
10.1
76
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2147030
106757
Rat
RGD:1594167
680264
Dog
cation channel sperm associated auxiliary subunit delta
VGNC:38748
476736
Horse
cation channel sperm associated auxiliary subunit delta
VGNC:16084
100065076
Cow
cation channel sperm associated auxiliary subunit delta
VGNC:26797
617472
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
cation channel sperm associated auxiliary subunit delta
Horse
cation channel sperm associated auxiliary subunit delta
Cow
cation channel sperm associated auxiliary subunit delta
Publication Statistics
PubMed Score 1.13
PubMed score by year
PubTator Score 0.33
PubTator score by year