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Tbio
FBXO11
F-box only protein 11

Protein Summary
Description
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein liga ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402508
  • ENSP00000385398
  • ENSG00000138081
  • ENST00000403359
  • ENSP00000384823

Symbol
  • FBX11
  • PRMT9
  • VIT1
  • UBR6
  • VIT1
  • FBX11
  • PRMT9
  • IDDFBA
  • UG063H01
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor
0.8
transcription factor perturbation
0.8
transcription factor binding site profile
0.79
histone modification site profile
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.83   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 317   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.83   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 317   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Protein-Protein Interactions (398)
1 – 10 of 398
PRDM5
Tbio
Family: TF; Epigenetic
Novelty: 0.01560016
p_int: 0.999966395
p_ni: 0.000033605
Score: 0.172
Data Source: BioPlex,STRINGDB
STAU1
Tbio
Novelty: 0.00542197
p_int: 0.999913704
p_ni: 0.000086296
Data Source: BioPlex
LBHD1
Tdark
p_int: 0.999865898
p_ni: 0.000134102
Data Source: BioPlex
SCML4
Tdark
Novelty: 1.0412832
p_int: 0.999351016
p_ni: 0.000648982
p_wrong: 2e-9
Score: 0.217
Data Source: BioPlex,STRINGDB
ZNF692
Tbio
Family: TF
Novelty: 0.06511123
p_int: 0.998842414
p_ni: 0.001157586
Data Source: BioPlex
CCDC107
Tdark
p_int: 0.998717589
p_ni: 0.001282411
Data Source: BioPlex
MYLK2
Tchem
Family: Kinase
Novelty: 0.00918962
p_int: 0.99866972
p_ni: 0.001330279
Score: 0.177
Data Source: BioPlex,STRINGDB
IKZF5
Tbio
Family: TF
Novelty: 1
p_int: 0.997416781
p_ni: 0.002583219
Score: 0.173
Data Source: BioPlex,STRINGDB
SKP1
Tbio
Family: Enzyme
Novelty: 0.00209659
p_int: 0.99724108
p_ni: 0.00275887
p_wrong: 5.1e-8
Score: 0.98
Data Source: BioPlex,STRINGDB
AP3S1
Tbio
Novelty: 0.23622047
p_int: 0.996568458
p_ni: 0.003431542
Data Source: BioPlex
Publication Statistics
PubMed Score  26.83

PubMed score by year
PubTator Score  22.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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